848301-94-0
中文名称
G3-C12
英文名称
G3-C12
CAS
848301-94-0
分子式
C74H115N23O23S2
分子量
1758.99
MOL 文件
848301-94-0.mol
更新日期
2024/05/06 11:54:51
848301-94-0 结构式
基本信息
英文别名
G3-C12L-Arginine, L-alanyl-L-asparaginyl-L-threonyl-L-prolyl-L-cysteinylglycyl-L-prolyl-L-tyrosyl-L-threonyl-L-histidyl-L-α-aspartyl-L-cysteinyl-L-prolyl-L-valyl-L-lysyl-
常见问题列表
生物活性
G3-C12 是 galectin-3 结合肽，Kd 值为 88 nM，具有抗肿瘤活性。靶点
Kd: 88 nM (Galectin-3)
体外研究
G3-C12 is a galectin-3 binding peptide, with high affinity (K d ) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer.