85079-48-7

中文名称 BREVETOXIN PBTX-3

英文名称 BREVETOXIN PBTX-3

CAS 85079-48-7

分子式 C50H72O14

分子量 897.1

MOL 文件 85079-48-7.mol

85079-48-7 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

短裸甲藻毒素3
化合物 T10609

英文别名

PBTX-3
toxint-17
Gb 3 toxin
BREVETOXIN3
PUMILIOTOXIN
brevetoxint17
BREVETOXIN PBTX-3
DIHYDROBREVETOXIN B
BKMHDYJRAAJTAD-RXUQWMQDSA-N
42-Hydroxy-42-deoxobrevetoxin B

物理化学性质

密度1.190±0.06 g/cm3(Predicted)

储存条件-20C

溶解度DMSO: soluble,Ethanol: soluble,Methanol: soluble

酸度系数(pKa)13.78±0.70(Predicted)

形态固体

颜色White to off-white

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS06,GHS09

警示词危险

危险性描述H300-H410

防范说明P264-P270-P273-P301+P310-P391-P405

危险品运输编号3172

RTECS号XW5885000

危险等级6.1(a)

包装类别I

常见问题列表

生物活性

Brevetoxin-3 (PbTx-3) 是一种有效的变构电压门控 Na+ 通道 (Na+ channels) 激活剂，具有多个活性中心 (A 环内酯，R 侧链的 C-42)。Brevetoxin-3 (PbTx-3) 对电压敏感的 Na+ 通道的位点 5 具有高亲和力，抑制 Na+ 通道的失活并延长这些通道的平均打开时间。Brevetoxin-3 (PbTx-3) 可导致气道高反应性 (AHR) 延长和肺部炎症。

靶点

IC50: voltage-gated Na ⁺ channel

体外研究

Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV).

体内研究

Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues. .

Animal Model:	Pregnant CD-1 mice
Dosage:	2.8 μg/kg
Administration:	Intratracheal instillation; 2.8 μg/kg; gestational days 15–18
Result:	Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure.