86583-19-9
![86583-19-9 结构式](/CAS/20211123/GIF/86583-19-9.gif)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 1mg | 1713元 |
2024/04/30 | HY-W013332A | 3-DEAZAADENOSINE HYDROCHLORIDE 3-Deazaadenosine hydrochloride | 86583-19-9 | 10mM * 1mLin DMSO | 2597元 |
2024/04/30 | S0787 | 3-Deazaadenosine hydrochloride | 86583-19-9 | 10mM (1mL in DMSO) | 2694.51元 |
常见问题列表
Target | Value |
S-adenosylhomocysteine hydrolase
(Cell-free assay) | 3.9 μM(Ki) |
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 µM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 µM, respectively. 3-Deazaadenosine (1-100 µM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 µM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 µM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 µM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.