872506-67-7
中文名称
(S)-1-((3-氯-2-甲基苯基)磺酰基)-N-环己基哌啶-3-甲酰胺
英文名称
(3S)-1-[(3-chloro-2-methylbenzene)sulfonyl]-
N-cyclohexylpiperidine-3-carboxamide
CAS
872506-67-7
分子式
C19H27ClN2O3S
分子量
398.95
MOL 文件
872506-67-7.mol
更新日期
2025/07/22 11:43:17
872506-67-7 结构式
基本信息
中文别名
11Β-HSD1抑制剂12(S)-1-((3-氯-2-甲基苯基)磺酰基)-N-环己基哌啶-3-甲酰胺
英文别名
(3S)-1-[(3-chloro-2-methylbenzene)sulfonyl]-
N-cyclohexylpiperidine-3-carboxamide应用领域
用途一
INCB13739 is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) for the treatment of type 2 diabetes. INCB-13739 has high selectivity for 11beta-HSD1 over other dehydrogenases and glucocorticoid and mineralocorticoid receptors, with prolonged pharmacodynamic activity and good pharmacokinetic/pharmacodynamic properties. INCB-13739 demonstrated improved hepatic and peripheral insulin sensitivity with a satisfactory reduction in fasting plasma glucose and cholesterol