874450-44-9
中文名称
SEN 12333
英文名称
SEN 12333
CAS
874450-44-9
分子式
C20H25N3O2
分子量
339.43
MOL 文件
874450-44-9.mol
更新日期
2024/05/11 14:52:46
874450-44-9 结构式
基本信息
中文别名
化合物SEN 123335-吗啉代-N-(4-(吡啶-3-基)苯基)戊酰胺
英文别名
SEN 12333WAY 317538
SEN 12333 WAY-317538
N-[4-(3-Pyridinyl)phenyl]-4-MorpholinepentanaMide
5-Morpholino-N-(4-(pyridin-3-yl)phenyl)pentanamide
4-MorpholinepentanaMide, N-[4-(3-pyridinyl)phenyl]-
应用领域
用途1
SEN 12333 is a nicotinic acetylcholine receptor (nAChR) agonist. SEN 12333 displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAC hRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. SEN 12333 is a brain penetrant and orally bioavailable.