91833-49-7
中文名称
罗卡斯汀
英文名称
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione
CAS
91833-49-7
分子式
C13H19N3OS
分子量
265.37
MOL 文件
91833-49-7.mol
91833-49-7 结构式
基本信息
中文别名
罗卡斯汀 英文别名
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f][1,4]oxazepine-5(2H)-thione
Pyrido[3,2-f]-1,4-oxazepine-5(2H)-thione, 2-[2-(dimethylamino)ethyl]-3,4-dihydro-4-methyl-
物理化学性质
熔点130-133 °C
沸点379.0±52.0 °C(Predicted)
密度1.20±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)9.18±0.28(Predicted)
常见问题列表
生物活性
Rocastine 是一种选择性的，非镇静的 H1 拮抗剂，为抗组胺剂。体内研究
Rocastine is effective with a 15 min pretreatment time (PD 50 = 0.13 mg/kg) as it is with a 1 hr pretreatment time (PD 50 = 0.12 mg/kg). Rocastine protects guinea pigs from collapse induced by aerosolized antigen; rocastine is approximately 36x more potent than diphenhydramine and as potent as oxatomide and terfenadine. Rocastine does not alter the EEG of cats at doses in vast excess (150x) of its antihistaminic dose nor does it potentiate yohimbine toxicity in mice.