924537-98-4
中文名称
319H6
英文名称
BT-13
CAS
924537-98-4
分子式
C23H27F4N3O4S
分子量
517.54
MOL 文件
924537-98-4.mol
更新日期
2025/10/10 17:14:19
924537-98-4 结构式
基本信息
中文别名
化合物BT-13 英文别名
319H6BT 13 NEW
BT-13 (RET agonist BT13)
Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-
物理化学性质
沸点637.0±65.0 °C(Predicted)
密度1.326±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 25 mg/mL (48.31 mM)
酸度系数(pKa)0.42±0.20(Predicted)
形态Solid
颜色White to off-white
BT-13价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-124401 | BT-13 | 924537-98-4 | 1 mg | 650元 |
| 2025/05/22 | HY-124401 | BT-13 | 924537-98-4 | 5 mg | 1700元 |
| 2025/05/22 | HY-124401 | BT-13 | 924537-98-4 | 10 mM * 1 mLin DMSO | 1936元 |
常见问题列表
生物活性
BT-13 是有效的、胶质细胞源性神经营养因子 (GDNF) 受体 RET 的选择性激动剂 (独立于 GDNF 配体发挥作用)，促进体外感觉神经元神经突生长，减轻大鼠神经病变的发生。靶点
GDNF receptor RET.
体外研究
BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.
体内研究
BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy.
| Animal Model: | Rats induced by ligation of left L5 and L6 spinal nerves. |
| Dosage: | 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. |
| Administration: | Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12. |
| Result: | 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia. |