93363-11-2
中文名称
3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide
英文名称
3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide
CAS
93363-11-2
分子式
C12H11N3OS
分子量
245.3
MOL 文件
93363-11-2.mol
更新日期
2023/03/17 20:03:08
93363-11-2 结构式
基本信息
中文别名
化合物 T10159化合物48740 RP
英文别名
48740RpRp 55779
48740 Rp
RP-48740
3-(3-Pyridinyl)-1H-pyrrolo[1,2-c]thiazole-7-carboxamide
3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide
1H,3H-Pyrrolo(1,2-C)thiazole-7-carboxamide, 3-(3-pyridinyl)-
常见问题列表
生物活性
48740 RP (RP-55778) 是一种血小板激活因子 (PAF) 拮抗剂。靶点
PAF
体内研究
48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability.