99247-33-3

中文名称 4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐

英文名称 PROGLUMIDE, SODIUM SALT

CAS 99247-33-3

分子式 C18H25N2NaO4

分子量 356.39

MOL 文件 99247-33-3.mol

99247-33-3 结构式

基本信息物理化学性质安全数据 4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐价格(试剂级) 常见问题列表

基本信息

中文别名

丙谷胺钠
4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐

英文别名

PROGLUMIDE SODIUM
PROGLUMIDE, SODIUM SALT
Proglumide sodium salt solid
4-benzamido-5-(dipropylamino)-5-oxopentanoate
PROGLUMIDE SODIUM SALT SELECTIVE CHOLECY STOK
dl-4-benzamido-n,n-dipropylglutaramicacidsodiumsalt
SODIUM
4-BENZAMIDO-5-(DIPROPYLAMINO)-5-OXOPENTANOATE
4-benzamido-n,n-dipropyl-,sodiumsalt,dl-glutaramicaci
4-BENZOYLAMINO-5-DIPROPYLAMINO-5-OXOPENTANOIC ACID SODIUM
Glutaramic acid, 4-benzamido-N,N-dipropyl-, sodium salt, DL-

物理化学性质

储存条件Desiccate at RT

溶解度H₂O: soluble

溶解度可溶于水中

形态solid

颜色white

水溶解性溶于水至100mM

安全数据

WGK Germany3

4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/01/25	HY-103354	4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐 Proglumide sodium	99247-33-3	50mg	600元
2024/01/25	HY-103354	4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐 Proglumide sodium	99247-33-3	10mM * 1mLin Water	660元
2024/01/25	HY-103354	4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐 Proglumide sodium	99247-33-3	100mg	1100元

常见问题列表

生物活性

Proglumide sodium 是一种非肽和口服活性胆囊收缩素 (CCK)-A/B 受体拮抗剂。Proglumide sodium 选择性阻断 CCK 在中枢神经系统中的作用。Proglumide sodium 具有抑制胃分泌和保护胃十二指肠粘膜的能力，还具有抗癫痫和抗氧化活性。

靶点

Cholecystokinin (CCK)-A/B receptors

体外研究

In an in vitro study, Proglumide at concentrations between 0.3-10 mM inhibits CCK-stimulated amylase release dose-dependently, while Proglumide does not influence the basal amylase release at concentrations between 0-3 mM. Dose-response curves to CCK for amylase release shifted to the right with increase in Proglumide concentration. This inhibition by Proglumide is reversible. In addition, the effect of Proglumide is selective for CCK and its related peptide.
The incubation of HT29 cells with Proglumide significantly reduces the [ ³ H]-thymidine incorporation to HT29 cells in a dose-dependent manner, with an IC ₅₀ of 6.5 mM. Proglumide reduces in a dose-dependent manner the percentage of necrosis with a parallel increase of apoptosis up to 70%.

体内研究

Proglumide (250-750 mg/kg; intraperitoneal injection; adult male Sprague Dawley rats) treatment is significantly effective in ameliorating the seizure activities, cognitive dysfunctions, and cerebral oxidative stress.

Animal Model:	Adult male Sprague Dawley rats (200-250 g; 2 months old) are induced status epilepticus (SE)
Dosage:	250 mg/kg, 500 mg/kg, and 750 mg/kg
Administration:	Intraperitoneal injection
Result:	Dose-dependently and significantly increased the latencies to seizure and SE. Significantly and dose-dependently attenuated Li-PC (SE) induced increase in thiobarbituric acid (TBARS) and catalase (CAT), attenuated Li-Pc induced decrease in SOD, and attenuated depletion of GSH and glutathione-S transferase (GST) in the hippocampus and striatum.