99957-90-1

中文名称 19-(ethyldithio)androst-4-ene-3,17-dione

英文名称 19-(ethyldithio)androst-4-ene-3,17-dione

CAS 99957-90-1

分子式 C21H30O2S2

分子量 378.59

MOL 文件 99957-90-1.mol

99957-90-1 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T12319
化合物 ORG30958

英文别名

ORG-30958
Org-30958,Org30958
19-(ethyldithio)androst-4-ene-3,17-dione
Androst-4-ene-3,17-dione, 19-(ethyldithio)- (9CI)

物理化学性质

沸点532.1±50.0 °C(Predicted)

密度1.19±0.1 g/cm3(Predicted)

常见问题列表

生物活性

Org30958 是体内有效的芳香酶 (aromatase) 抑制剂。

靶点

Aromatase

体内研究

Besides inhibition of cornification of vaginal epithelium Org30958 (ORG 30958) decreases ovarian aromatase and plasma E2 levels in DHEAS-treated hypophysectomized rats. Plasma estradiol levels are also lowered by Org30958 in dogs which are treated with pregnant mare serum gonadotrophin in order to induce pro-estrus. Org30958 displays much less than 1/400th of the androgenic activity of testosterone propionate in immature castrated rats and appears to be devoid of estrogenic and anti-estrogenic activity in ovariectomized mature rats. A twice daily dose of 1.5 mg Org30958/kg postpones ovulation in mature female rats.