L-墨蝶呤
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- CAS号:
- 17094-01-8
- 英文名:
- L-SEPIAPTERIN
- 英文别名:
- SEPIAPTERIN;L-SEPIAPTERIN;L-Sepiapterin,98%;Sepiapterin solid;L-SEPIAPTERIN DIHYDRATE;LSepiapterin,L Sepiapterin;Sepiapterin (L-Sepiapterin);L -SEPIAPTERIN DIHYDRATE 99+%;Clomifene Impurity 2(Clomifene EP Impurity B);SEPIAPTERIN (L-SEPIAPTERIN) COFACTOR OF NITRIC OX
- 中文名:
- L-墨蝶呤
- 中文别名:
- 墨蝶呤;L-墨蝶呤;墨蝶蛉(L-墨蝶蛉);乌贼乙素(L-乌贼乙素);(S)-2-氨基-6-(2-羟基丙酰基)-7,8-二氢蝶啶-4(3H)-酮;S-(-)-2-氨基-7,8-二氢-6-(2-羟基-1-氧代丙基)-4(1H)-蝶啶酮
- CBNumber:
- CB0116110
- 分子式:
- C9H11N5O3
- 分子量:
- 237.22
- MOL File:
- 17094-01-8.mol
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L-墨蝶呤化学性质
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熔点:
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>270 °C (dec.)
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沸点:
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448.1±55.0 °C(Predicted)
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密度:
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1.86±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: 27 mg/mL
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形态:
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solid
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酸度系数(pKa):
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12.33±0.20(Predicted)
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颜色:
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yellow
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稳定性:
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Light Sensitive
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CAS 数据库:
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17094-01-8
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L-墨蝶呤性质、用途与生产工艺
L-Sepiapterin (Sepiapterin) 是内皮型一氧化氮合酶 (eNOS) 辅因子四氢生物喋呤 (BH4) 的前体。L-Sepiapterin 改善 db/db 小鼠肠系膜小动脉内皮功能障碍，诱导血管生成。L-Sepiapterin 通过下调 p70S6K 依赖性 VEGFR-2 表达抑制卵巢癌细胞增殖和迁移。
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Human Endogenous Metabolite
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L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner.
L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70
S6K
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L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism.
Cell Proliferation Assay
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Cell Line:
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SKOV-3 cells
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Concentration:
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0.1, 1, 10 μM
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Incubation Time:
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24 hours
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Result:
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Induced cell proliferation in a dose-dependent manner.
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Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice.
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Animal Model:
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Male C57BL/KsJ diabetic mice (db/db)
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Dosage:
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10 mg/kg
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Administration:
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P.o. (powder chow); daily for or 8 weeks
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Result:
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Significantly improved the relaxation to Ach in SMA from db/db mice.
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L-墨蝶呤
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-112234 | L-墨蝶呤
L-Sepiapterin | 17094-01-8 | 1mg | 4500元 |
L-墨蝶呤
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17094-01-8, L-墨蝶呤 相关搜索:
- 抑制剂
- 对照品
- Heterocyclic Building Blocks
- Others
- Chiral Building Blocks
- Asymmetric Synthesis
- C9H11N5O3
- C9H11N5O32H2O
- (S)-2-氨基-6-(2-羟基丙酰基)-7,8-二氢蝶啶-4(3H)-酮
- 墨蝶蛉(L-墨蝶蛉)
- 乌贼乙素(L-乌贼乙素)
- L-墨蝶呤
- 墨蝶呤
- S-(-)-2-氨基-7,8-二氢-6-(2-羟基-1-氧代丙基)-4(1H)-蝶啶酮
- 17094-01-8
- Clomifene Impurity 2(Clomifene EP Impurity B)
- LSepiapterin,L Sepiapterin
- SEPIAPTERIN
- Sepiapterin (L-Sepiapterin)
- 4(3H)-Pteridinone,2-amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-
- 2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-1H-pteridin-4-one
- L-SEPIAPTERIN
- Sepiapterin,S-()-2-Amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-pteridinone, L-Sepiapterin
- L-Sepiapterin,98%
- 2-amino-6-(2-hydroxypropanoyl)-7,8-dihydro-1H-pty oeridin-4-one
- L -SEPIAPTERIN DIHYDRATE 99+%
- SEPIAPTERIN (L-SEPIAPTERIN) COFACTOR OF NITRIC OX
- 2-AMINO-7,8-DIHYDRO-6-(2S-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE
- L-SEPIAPTERIN DIHYDRATE
- S(-)-2-AMINO-7,8-DIHYDRO-6-(2-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE
- Sepiapterin solid
- (S)-2-AMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one
- (S)-2-aMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(1H)-one