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PREGNENOLONE MONOSULFATE

生物活性 靶点 体外研究 体内研究 PREGNENOLONE MONOSULFATE 试剂级价格
PREGNENOLONE MONOSULFATE, 1247-64-9, 结构式
PREGNENOLONE MONOSULFATE
CAS号:
1247-64-9
英文名:
(3S,8S,9R,10S,13S,14R,17R)-17-acetyl-10,13-dimethyl-3-sulfooxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene
英文别名:
Pregnenolone sulfate;Pregnenolone sulphate;Pregnenolone monosulfate;DIJBBUIOWGGQOP-OZIWPBGVSA-N;3β-Hydroxy-5-pregnen-20-one monosulfate;Pregn-5-en-20-one, 3-(sulfooxy)-, (3β)-;3β-Hydroxy-5-pregnen-20-one monosulfate;Di[(pregn-5-en-20-one)-3-yl] =sulfate ester;(3S,8S,9R,10S,13S,14R,17R)-17-acetyl-10,13-dimethyl-3-sulfooxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene
中文名:
PREGNENOLONE MONOSULFATE
中文别名:
糖酮硫酸盐;化合物 T12536
CBNumber:
CB01236206
分子式:
C21H32O5S
分子量:
396.54
MOL File:
1247-64-9.mol

PREGNENOLONE MONOSULFATE化学性质

密度:
1.25±0.1 g/cm3(Predicted)
储存条件:
Store at -20°C,stored under nitrogen
溶解度:
DMSO: 62.5 mg/mL (157.61 mM)
酸度系数(pKa):
-3.51±0.18(Predicted)
安全信息

PREGNENOLONE MONOSULFATE性质、用途与生产工艺

生物活性

Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) 是一种功能强大的神经甾体，是包括甾体酮在内的各种甾体激素的主要前体。Pregnenolone monosulfate 是大麻素 CB1 受体的信号传导特异性抑制剂，抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。Pregnenolone monosulfate 可以保护大脑免受大麻中毒。

靶点

CB1

Human Endogenous Metabolite

体外研究

CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy.
The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).

体内研究

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se . Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.

PREGNENOLONE MONOSULFATE 上下游产品信息

上游原料

下游产品

PREGNENOLONE MONOSULFATE 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/01/25HY-B1739PREGNENOLONE MONOSULFATE
Pregnenolone monosulfate		1247-64-95mg600元
2024/01/25HY-B1739PREGNENOLONE MONOSULFATE
Pregnenolone monosulfate		1247-64-910mM * 1mLin DMSO660元

PREGNENOLONE MONOSULFATE 生产厂家

全球有 15家供应商   PREGNENOLONE MONOSULFATE国内生产厂家
供应商联系电话电子邮件国家产品数优势度
上海喀露蓝科技有限公司 18149758185 sales-cpd@caerulumpharma.com 中国 3421 58
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司 021-61415566 800-8193336 orderCN@merckgroup.com 中国 51471 80
北京普西唐生物科技有限公司 010-60605840 18892239720 psaitong@jm-bio.com 中国 12308 58
济南药研药物化学有限公司 jnyaoyan@163.com 中国 3069 58
范德(北京)生物科技有限责任公司 15911056312 liming@bio-fount.com 中国 9730 58
南京美韬医药科技有限公司 meitaochem@126.com meitaochem@126.com 中国 19105 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
ChemeGen 中国 18818260767 sales@chemegen.com 中国 11289 58
成都思天德生物科技有限公司 028-83243028 19136088901 sinostandards@163.com 中国 5044 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29834 58
金瓯生物医药（南京）有限公司 13000000000 jinoupharma@163.com 中国 11732 58
江苏艾康生物医药研发有限公司 18626450290 yftan@aikonchem.com 中国 10718 58
上海麦克林生化科技股份有限公司 021-50706066 15221275939 shenlinxing@macklin.cn 中国 29803 58
 

1247-64-9, PREGNENOLONE MONOSULFATE 相关搜索:

  • C21H32O5S
  • 糖酮硫酸盐
  • 化合物 T12536
  • 1247-64-9
  • 3β-Hydroxy-5-pregnen-20-one monosulfate
  • Pregn-5-en-20-one, 3-(sulfooxy)-, (3β)-
  • 3β-Hydroxy-5-pregnen-20-one monosulfate
  • Pregnenolone monosulfate
  • DIJBBUIOWGGQOP-OZIWPBGVSA-N
  • Pregnenolone sulphate
  • Di[(pregn-5-en-20-one)-3-yl] =sulfate ester
  • (3S,8S,9R,10S,13S,14R,17R)-17-acetyl-10,13-dimethyl-3-sulfooxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene
  • Pregnenolone sulfate
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