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LY-315920

LY-315920, 172733-42-5, 结构式
LY-315920
CAS号:
172733-42-5
英文名:
NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT
英文别名:
LY 315920Na;LY 315920 sodium;Varespladib sodium;LY315920 sodiuM salt;VARESPLADIB SODIUM (LY315920 SODIUM SALT);NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT;[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid monosodium salt
中文名:
LY-315920
中文别名:
伐瑞拉地钠;伐瑞拉迪钠
CBNumber:
CB01475683
分子式:
C21H21N2NaO5
分子量:
404.4
MOL File:
172733-42-5.mol

LY-315920化学性质

形态:
Solid
颜色:
Off-white to light yellow
安全信息

LY-315920性质、用途与生产工艺

生物活性

Varespladib sodium (LY315920 sodium) 是一种有效且具有选择性的 group IIA, secretory phospholipase A2 (sPLA2) 抑制剂,其 IC50 值为 9 nM。Varespladib sodium 对大鼠,兔,豚鼠和人等各种物种血清的 sPLA2 活性具有明显的抑制作用,IC50 分别为 8.1 nM,5.0 nM,3.2 nM 和 6.2 nM。

靶点

sPLA2

9 nM (IC 50 )

体外研究

Varespladib sodium (10 μM; 24 and 48 hours; HCjE cells) treatment results in complete inhibition of the RA-induced increase in MUC16 protein detected in cell lysates at both time points.
Varespladib sodium (10 μM; 24 and 48 hours; HCjE cells) treatment significantly inhibits RA-induced MUC16 expression by 100% at 24 hours and 99% at 48 hours.

Western Blot Analysis

Cell Line: HCjE cells
Concentration: 10 μM
Incubation Time: 24 hours, 48 hours
Result: Significantly inhibited the RA-induced MUC16 protein expression at both time points.

RT-PCR

Cell Line: HCjE cells
Concentration: 10 μM
Incubation Time: 24 hours, 48 hours
Result: Significantly inhibited RA-induced MUC16 expression by 100% at 24 hours and 99% at 48 hours.

体内研究

Varespladib sodium treatment inhibits human sPLA 2 -induced release of thromboxane A 2 (TXA 2 ) from isolated guinea pig lung bronchoalveolar lavage cells with an IC 50 of 0.79 μM. And the ED 50 for Varespladib sodium is 16.1 mg/kg.

Animal Model: Male Hartley guinea pigs (300-500 g)
Dosage: 3 mg/kg, 10 mg/kg, and 30 mg/kg
Administration: Intravenous injection (Pharmacokinetic study)
Result: Consistent inhibition of sPLA2 activity in BAL fluid was observed. Reduced the human sPLA2-induced generation of TXA2 on BAL cells from guinea pigs.

LY-315920 上下游产品信息

上游原料

下游产品

LY-315920 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/08/19HY-13402AVarespladib sodium1 mg750元
2024/08/19HY-13402AVarespladib sodium5 mg1650元

LY-315920 生产厂家

全球有 9家供应商   LY-315920国内生产厂家
供应商联系电话电子邮件国家产品数优势度
Wuhan NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 中国 1494 55
上海一飞生物科技有限公司 021-65675885 18964387627 info@efebio.com 中国 9707 58
兰州安杰利生物化学科技有限公司 0931-8235634 13321316780 1455540579@qq.com 中国 959 55
学研惠(武汉)科技有限公司 15342225168 yutianchun2007@126.com 中国 10001 58
常州孚睿斯生物科技有限公司 0519-85524369 3477467573@qq.com 中国 8618 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29778 58
南京世洲生物科技有限公司 025-85560043 15850508050 cindy.huang@synzest.com 中国 12007 58
TargetMol中国(陶术生物) 15002134094 marketing@targetmol.cn 中国 28070 58
 

172733-42-5, LY-315920 相关搜索:

  • C21H20N2O5Na
  • 伐瑞拉地钠
  • 伐瑞拉迪钠
  • 172733-42-5
  • VARESPLADIB SODIUM (LY315920 SODIUM SALT)
  • Varespladib sodium
  • LY 315920Na
  • LY 315920 sodium
  • [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid monosodium salt
  • LY315920 sodiuM salt
  • NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT
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