182073-77-4
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- CAS号:
- 182073-77-4
- 英文名:
- N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE
- 英文别名:
- ZD8321;ZD-8321,ZD8321;N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE;L-Prolinamide, N-(methoxycarbonyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
- 中文名:
- 182073-77-4
- 中文别名:
- 化合物 ZD8321;化合物 T17288
- CBNumber:
- CB01476918
- 分子式:
- C18H28F3N3O5
- 分子量:
- 423.43
- MOL File:
- 182073-77-4.mol
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182073-77-4化学性质
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沸点:
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573.9±50.0 °C(Predicted)
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密度:
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1.232±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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11.22±0.46(Predicted)
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颜色:
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Light yellow to yellow
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182073-77-4性质、用途与生产工艺
ZD8321 是人 Neutrophil elastase (NE) 的有效抑制剂，其 Ki 值为 13±1.7 nM。
Ki: 13±1.7 nM (Neutrophil elastase)
TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321.
182073-77-4
上下游产品信息
上游原料
下游产品
182073-77-4, 182073-77-4 相关搜索:
- 抑制剂
- C18H28F3N3O5
- 化合物 ZD8321
- 化合物 T17288
- 182073-77-4
- ZD-8321,ZD8321
- L-Prolinamide, N-(methoxycarbonyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
- ZD8321
- N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE