113418-56-7
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- CAS号:
- 113418-56-7
- 英文名:
- 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione
- 英文别名:
- Wy-49051;3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione;1H-Purine-2,6-dione, 7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-3,7-dihydro-1,3-dimethyl-
- 中文名:
- 113418-56-7
- 中文别名:
- 化合物 T13352;化合物WY 49051
- CBNumber:
- CB02425188
- 分子式:
- C28H33N5O3
- 分子量:
- 487.59
- MOL File:
- 113418-56-7.mol
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113418-56-7化学性质
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沸点:
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672.7±65.0 °C(Predicted)
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密度:
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1.25±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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8.32±0.10(Predicted)
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113418-56-7性质、用途与生产工艺
Wy 49051 是一种有效的，可口服的 H1 receptor 拮抗剂，IC50 值为 44 nM。
IC50: 44 nM (H1 receptor)
Wy 49051 shows great inhibitory effect on H1, producing 92% inhibition of the histamine-induced contraction of the guinea pig ileum at a concentration 100 nM. Wy 49051 is the most potent compound with 700 times the potency of astemazole, 470 times the potency of chlorpheniramine. Wy 49051 also has high affinity for α1 receptor with IC
50
of 8 nM.
Wy 49051 shows potent activity against histamine-induced lethality in the guinea pig, with ED
50
of 1.91 mg/kg by po, 0.70 mg/kg by ip, and 0.01 mg/kg by iv. The duration of action of 24 is also favorable since there is no decrease in oral efficacy up to 18 h posttreatment.
113418-56-7
上下游产品信息
上游原料
下游产品
113418-56-7, 113418-56-7 相关搜索:
- 化合物WY 49051
- 化合物 T13352
- 113418-56-7
- 1H-Purine-2,6-dione, 7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-3,7-dihydro-1,3-dimethyl-
- Wy-49051
- 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione