冈田(软海绵)酸
|
|
|
- CAS号:
- 78111-17-8
- 英文名:
- OKADAIC ACID
- 英文别名:
- OA;CS-759;NSC 677083;Okadic acid;Ocadaic Acid;OKADAIC ACID;HALOCHONDRINE A;Okadaic acid,97%;35-Demethyl-DTX 1;OKADAIC ACID, 98+%
- 中文名:
- 冈田(软海绵)酸
- 中文别名:
- 冈田酸;黑海棉酸;软海绵酸;冈田酸钠盐;大田软海绵酸;冈田酸游离酸;冈田酸/软海绵酸;冈田(软海绵)酸;软海绵酸,游离酸;软海绵酸(-20°C)
- CBNumber:
- CB0246204
- 分子式:
- C44H68O13
- 分子量:
- 805
- MOL File:
- 78111-17-8.mol
|
|
|
冈田(软海绵)酸化学性质
-
熔点:
-
164-166 °C
-
|
-
比旋光度:
-
D20 +21° (c = 0.33 in CHCl3); D25 +25.4° (c = 0.24 in CHCl3)
-
|
-
沸点:
-
672.95°C (rough estimate)
-
|
-
密度:
-
1.0795 (rough estimate)
-
|
-
折射率:
-
1.5940 (estimate)
-
|
-
储存条件:
-
-20°C
-
|
-
溶解度:
-
DMSO: ≥1 mg/mL
-
|
-
形态:
-
translucent film
-
|
-
酸度系数(pKa):
-
3.87±0.16(Predicted)
-
|
-
颜色:
-
translucent
-
|
-
水溶解性:
-
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.
-
|
-
Merck:
-
13,6891
-
|
-
稳定性:
-
Stable. Light and heat-sensitive. Combustible. Incompatible with strong oxidizing agents.
-
|
-
CAS 数据库:
-
78111-17-8
-
|
-
EPA化学物质信息:
-
1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoic acid, .alpha,5-dihydroxy-.alpha.,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-, (.alpha.R,2S,5R,6R,8S)- (78111-17-8)
-
|
冈田(软海绵)酸性质、用途与生产工艺
Okadaic acid 是从 Halichondria 属的黑色海绵中提取的。Okadaic acid 是一种非竞争性，选择性和可逆的丝氨酸/苏氨酸特异性蛋白磷酸酶 1 (PP1)，PP2A 和 PP3 的抑制剂，IC50 分别为 10-15 nM，0.5 nM 和 4 nM。Okadaic acid 通过细胞凋亡消除后生共生体/寄生虫。
IC50: 10-15 nM (PP1), 0.5 nM (PP2) and 4 nM (PP3)
类别
有毒物品
毒性分级
剧毒
急性毒性
腹腔-小鼠 LD50: 0.192 毫克/公斤
可燃性危险特性
可燃, 火场排出辛辣刺激烟雾
储运特性
库房低温, 通风, 干燥; 与食品原料分开存放
灭火剂
水, 二氧化碳, 干粉, 砂土
冈田(软海绵)酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-N6785 | 冈田(软海绵)酸
Okadaic acid | 78111-17-8 | 25μg(124.2μM * 250μL in Ethanol) | 2300元 |
| 2024/01/16 | C32837 | 冈田酸
Okadaic acid, 97% | 78111-17-8 | 0.1mg | 9914元 |
冈田(软海绵)酸
生产厂家
全球有 153家供应商
冈田(软海绵)酸国内生产厂家
78111-17-8, 冈田(软海绵)酸 相关搜索:
- Protein Phosphatase
- Signalling
- Inhibitor
- Natural Products
- 试剂盒-细胞分析试剂盒
- 化合物
- 医药原料
- 生化试剂
- 其他生化试剂
- Enzyme Inhibitors
- Enzyme Inhibitors by Type
- Enzyme Inhibitors by Enzyme
- Enzymes, Inhibitors, and Substrates
- Serine/Threonine Phosphatase Inhibitors
- Substrate Analogs
- Kinase/Phosphatase Biology
- Protein Phosphatase 1 (PP1)
- Protein phosphatase-1, Catalytic Subunit
- P to Q
- Cell Biology
- Cell Signaling and Neuroscience
- Biochemicals and Reagents
- BioChemical
- C44H68O13
- 大田软海绵酸/冈田酸/黑海绵酸
- 软海绵酸,游离酸
- 冈田酸游离酸
- 大田软海绵酸
- 冈田(软海绵)酸溶液,10PPM
- 35-去甲基鳍藻毒素 1
- 软海绵酸(>95.0%,BC)
- 冈田酸/软海绵酸
- 黑海棉酸
- 软海绵酸
- 软海绵酸(-20°C)
- 冈田酸钠盐
- 冈田(软海绵)酸
- 冈田酸
- 78111-17-8
- Carbovir Impurity 2
- 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-,(aR,2S,5R,6R,8S)-
- (2R)-3-[(2S,6R,8S,11R)-2-[(E)-4-[(2R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2R,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5''-oxolane]-2''-yl]but-3-en-2-yl]-11-hydroxy-4-
- CS-759
- OKADAIC ACID
- Okadaic acid, free acid >98%
- Okadaic acid from Prorocentrum concavum,OA
- Blue mussel, homogenized (Okadaic acid)
- Okadaic acid,97%
- Okadic acid
- Ocadaic Acid
- 9,45-Seco-10-demercapto-9,10-didehydroacanthifolicin
- OKADAICACID,HIGHPURITY
- 1,7-Dioxaspiro5.5undec-10-ene-2-propanoic acid, .alpha.,5-dihydroxy-.alpha.,10-dimethyl-8-(1R,2E)-1-methyl-3-(2R,4aR,5R,6S,8R,8aS)-octahydro-8-hydroxy-6-(1S,3S)-1-hydroxy-3-(2S,3R,6S)-3-methyl-1,7-dioxaspiro5.5undec-2-ylbutyl-7-methylenespirofuran-2(3H),2
- Okadaicacid,Prorocentrumconcavum,highpurity
- OKADAIC ACID, 98+%
- 9,10-deepithio-9,10-didehydro-acanthifolici
- OKADAIC ACID SODIUM SALT 98+%
- OKADAIC ACID FROM PROROCENTRUM SP.