缬沙坦苄酯

缬沙坦苄酯性质、用途与生产工艺

理化性质

用途

合成方法

将苄基N-戊酰基- N - [ { 2 '-[1-(三苯甲基)-1H-四唑-5-基]]-1，1 ' -联苯- 4 -基}甲基] - L -缬氨酸_( 330 mg )溶于6 m L甲醇中，将所得的反应体系在加热状态下回流反应2 h，然后转移到室温反应过夜。反应结束后反应液在减压状态下蒸干，然后将残余物通过硅胶(洗脱剂:环己烷/乙酸乙酯从7 : 3到3 : 7)柱层析分离纯化即可得到缬沙坦苄酯( 207 mg ,产率为92 %)。

图 缬沙坦苄酯的合成路线

缬沙坦苄酯 上下游产品信息

上游原料

下游产品

缬沙坦苄酯 生产厂家

137863-20-8, 缬沙坦苄酯 相关搜索:

• Pharmaceuticals
• Intermediates & Fine Chemicals
• Heterocycles
• Aromatics
• Amino Acids & Derivatives
• 杂质对照品
• 标准品
• 对照品-杂质对照品
• 医药中间体
• C31H35N5O3
• 缬沙坦杂质2(缬沙坦USP RC C)
• 缬沙坦EP杂质B(缬沙坦USP相关化合物C)
• 缬沙坦EP杂质B(缬沙坦苄酯)
• 缬沙坦杂质27
• 缬沙坦USP RC C
• 苄基缬沙坦
• 缬沙坦相关物质C USP标准品
• 缬沙坦杂质CGP49841
• 缬沙坦USP杂质C；缬沙坦苄酯
• 缬沙坦USP杂质C
• 缬沙坦USP相关物质C
• 缬沙坦EP杂质B
• 缬沙坦苄酯
• 缬沙坦杂质C
• 缬沙坦相关物质C
• 原研CGP 49841
• N-戊酰基-N-[[2'-(1H-四唑-5-基)[1,1'-联苯]-4-基]甲基]-L-缬氨酸苄酯
• 缬沙坦 CGP49841
• 缬沙坦相关物C
• 137863-20-8
• Benzyl 2(S)-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
• L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, phenylmethyl ester (9CI)
• Valsartan Impurity C
• Valsartan Related CoMpound C
• Valsartan Related Compound C (N-valeryl-N-{[2''-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-L-valine be (1708795)
• Valsartan EP Impurity BQ: What is Valsartan EP Impurity B Q: What is the CAS Number of Valsartan EP Impurity B Q: What is the storage condition of Valsartan EP Impurity B Q: What are the applications of Valsartan EP Impurity B
• Valsartan Related Compound C (J0M318)
• Valsartan impurities27
• Valsartan EP Impurity B/ Valsartan Related Compound C (Valsartan Benzyl Ester)
• Valsartan Impurity 2（Valsartan USP RC C）
• Valsartan EP Impurity B (Valsartan USP Related Compound C)
• (S)-benzyl 2-(N-((2'-(1H-tetrazol-5-yl)
• Valsartan impurity 1/Valsartan EP Impurity B/(S)-Benzyl 2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
• Valsartan-1
• Valsartan Impurity 2（Valsartan Related Compound C）
• (S)-N-(1-benzyloxycarbonyl-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)bi-phenyl-4-ylmethyl]-amine
• BenzylN-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate
• Valsartan Impurity B
• Valsartan USP RC C
• benzyl N-((2'-(1H-tetrazol-5-yl)-[1,1'- biphenyl]-4-yl)methyl)-N-pentanoyl- L-valinate
• (S)-Benzyl 2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutan
• -Benzyl 2-(N-((2'-(1H-tetrazol-5-yl)
• -3-methylbutanoate
• (S)-benzyl 2-(N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate
• Valsartan EP Impurity B
• Valsartan Related Compound C (10 mg) (N-valeryl-N-{[2'-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-L-valine benzyl ester)
• Benzyl N-Pentanoyl-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-D-valine
• N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine phenylmethyl ester