Tie2 kinase inhibitor
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- CAS号:
- 948557-43-5
- 英文名:
- Tie2 kinase inhibitor
- 英文别名:
- Tie2 kinase-IN-1;Tie2 kinase inhibitor;Tie2 kinase inhibitor 1;Tie2 kinase inhibitor USP/EP/BP;4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole;4-(4-(6-Methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine;4-(5-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine;4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(Methylsulfinyl)phenyl]-1H-iMidazol-5-yl]pyridine;Pyridine, 4-[4-(6-methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-
- 中文名:
- Tie2 kinase inhibitor
- 中文别名:
- TIE2激酶抑制剂;4-(6-甲氧基-2-萘)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶)-1H-咪唑;4-(4-(6-甲氧基萘-2-基)-2-(4-(甲基亚磺酰基)苯基)-1H-咪唑-5-基)吡啶;5-氯-N2-[2-甲氧基-4-[4-(4-甲基-1-哌嗪基)-1-哌啶基]苯基]-N4-[2-[(1-甲基乙基)磺酰基]苯基]-2
- CBNumber:
- CB02510437
- 分子式:
- C26H21N3O2S
- 分子量:
- 439.53
- MOL File:
- 948557-43-5.mol
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Tie2 kinase inhibitor化学性质
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沸点:
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699.8±55.0 °C(Predicted)
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密度:
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1.39±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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≥22 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
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形态:
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Powder
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酸度系数(pKa):
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9.53±0.10(Predicted)
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颜色:
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Light yellow to yellow
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Tie2 kinase inhibitor性质、用途与生产工艺
Tie2 kinase inhibitor是SB-203580的优化产物,选择性作用于Tie2,IC50为0.25 μM,比作用于p38效果高200倍。
Tie2 kinase inhibitor 也具有适度细胞活性,作用于HEL细胞时,IC50为232 nM。而且, Tie2 kinase inhibitor 作用于Tie2 比p38 (IC50=50 μM)选择性高很多,而比 VEGFR2, VEGFR3,和 PDGFR1β选择性高10倍以上。
Tie2 kinase inhibitor按25 和 50 mg/kg剂量腹腔注射给药处理Matrigel 小鼠血管生成模型, 每天两次,导致血管生成分别降低41% 和70%。Tie2 kinase inhibitor 处理MOPC-315浆细胞移植瘤模型,导致肿瘤生长延迟,这种作用存在适度剂量依赖性。
Tie2 kinase inhibitor
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100556 | Tie2 kinase inhibitor 1 | | 1 mg | 690元 |
2024/08/19 | HY-100556 | Tie2 kinase inhibitor 1 | | 2 mg | 1075元 |
Tie2 kinase inhibitor
生产厂家
948557-43-5, Tie2 kinase inhibitor 相关搜索:
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Heterocycles
- Aromatics
- 药靶配体
- 合成有机化合物配体
- 蛋白酪氨酸激酶
- 小分子抑制剂,天然产物
- 5-氯-N2-[2-甲氧基-4-[4-(4-甲基-1-哌嗪基)-1-哌啶基]苯基]-N4-[2-[(1-甲基乙基)磺酰基]苯基]-2
- 4-(4-(6-甲氧基萘-2-基)-2-(4-(甲基亚磺酰基)苯基)-1H-咪唑-5-基)吡啶
- TIE2激酶抑制剂
- 4-(6-甲氧基-2-萘)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶)-1H-咪唑
- 948557-43-5
- Tie2 kinase inhibitor USP/EP/BP
- Pyridine, 4-[4-(6-methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-
- 4-(4-(6-Methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine
- Tie2 kinase inhibitor 1
- Tie2 kinase-IN-1
- 4-(5-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine
- 4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
- 4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(Methylsulfinyl)phenyl]-1H-iMidazol-5-yl]pyridine
- Tie2 kinase inhibitor