(4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物
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- CAS号:
- 106740-09-4
- 英文名:
- GYY 4137 Morpholine salt
- 英文别名:
- ZYJ1122;ZYJ 1122;GYY 4137;ZYJ-1122.;GYY 4137 MORPHOLINE SALT;GYY4137;GYY-4137;GYY 4137;Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate;morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate;4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt;P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
- 中文名:
- (4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物
- 中文别名:
- 4-甲氧基苯基硫代磷酸酯(吗啉)吗啉盐;GYY 4137,水溶性,缓释H 2 S供体;(4-甲氧基苯基)(吗啉)二硫代单膦酸吗啉盐;(4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物;化合物GYY 4137 MORPHOLINE SALT;4-甲氧基苯基硫代磷酸酯(吗啉)吗啉盐 4-METHOXYPHENYL(MORPHOLINO)PHOSPHINODITHIOATE MORPHOLINIUM SALT
- CBNumber:
- CB02538277
- 分子式:
- C15H25N2O3PS2
- 分子量:
- 376.474361
- MOL File:
- 106740-09-4.mol
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(4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物化学性质
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熔点:
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164-166℃
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溶解度:
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DMF: 20 mg/ml; DMSO: 15 mg/ml; PBS (pH 7.2): 3 mg/ml
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形态:
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White solid.
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颜色:
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White
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(4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物性质、用途与生产工艺
GY4137 是一种缓释 H2S 供体，具有血管扩张和抗高血压活性。GY4137 还具有抗炎和抗癌活性。
GYY4137 (400-800 µM) causes concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38).
GYY4137 (0.1-0.5 mM) decreases LPS-induced production of nitrite (NO2−), PGE2, TNF-α and IL-6 from human synoviocytes (HFLS) and articular chondrocytes (HAC), reduces the levels and catalytic activity of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and reduced LPS-induced NF-κB activation.
Cell Viability Assay
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Cell Line:
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HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS
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Concentration:
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400 or 800 µM
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Incubation Time:
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5 days
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Result:
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Significantly affected cancer cell survivability.
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GYY4137 (100-300 mg/kg; i.p.; daily for 14 days) significantly reduces the tumor volume in both animal models, in a dose-dependent manner.
In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 (50 mg/kg, i.p.) injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, was apparent when GYY4137 was injected 6 hrs after CFA.
GYY4137 significantly inhibited tumor growth in the subcutaneous HepG2 xenograft model by inhibiting STAT3 activation and its target gene expression.
GYY4137 prevents nitrative stress and α-synuclein nitration in an MPTP mouse model of parkinson’s disease.
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Animal Model:
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Female, severe combined immunodeficiency (SCID) mice (bearing HL-60 or MV4-11 cells)
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Dosage:
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100, 200 and 300 mg/kg
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Administration:
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I.p.; daily for 14 days
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Result:
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Reduced tumor volume by 52.5±9.2% and 55.3±5.7% in HL-60 and MV4–11 injected animals.
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(4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-107632 | GYY4137 | | 5 mg | 350元 |
| 2024/01/25 | HY-107632 | (4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物
GYY4137 | 106740-09-4 | 10mg | 550元 |
(4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物
生产厂家
106740-09-4, (4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物 相关搜索:
- 药靶配体
- 有机化学
- 试剂盒-细胞分析试剂盒
- 抑制剂
- C4H9NOC11H16NO2PS2
- C11H16NO2PS2C4H9NO
- GYY 4137,水溶性,缓释H 2 S供体
- (4-甲氧基苯基)(吗啉)二硫代单膦酸吗啉盐
- 化合物GYY 4137 MORPHOLINE SALT
- 4-甲氧基苯基硫代磷酸酯(吗啉)吗啉盐
- 4-甲氧基苯基硫代磷酸酯(吗啉)吗啉盐 4-METHOXYPHENYL(MORPHOLINO)PHOSPHINODITHIOATE MORPHOLINIUM SALT
- (4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物
- 106740-09-4
- Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate
- ZYJ-1122.
- ZYJ1122
- ZYJ 1122
- 4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt
- (4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium
- morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate
- GYY4137;GYY-4137;GYY 4137
- P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
- (4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine
- GYY 4137
- GYY 4137 MORPHOLINE SALT