网站主页 >> CAS数据库列表 >> (S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
(S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
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- CAS号:
- 685898-44-6
- 英文名:
- L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
- 英文别名:
- CS-1467;PX-478 HCl;PX478 2HCl;ALKN004012;PX 478
DISCONTINUED;PX-478 dihydrochloride;4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine dihydrochloride;4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2);L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1;Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
- 中文名:
- (S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
- 中文别名:
- 化合物PX-478 2HCL;(S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
- CBNumber:
- CB02628046
- 分子式:
- C13H19Cl3N2O3
- 分子量:
- 357.66
- MOL File:
- 685898-44-6.mol
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(S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐化学性质
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储存条件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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≥19.7 mg/mL in DMSO; ≥50 mg/mL in H2O; ≥8.42 mg/mL in EtOH
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形态:
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Powder
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CAS 数据库:
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685898-44-6
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(S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐性质、用途与生产工艺
PX-478 2HCl是一种具有口服活性的选择性hypoxia-inducible factor-1α (HIF-1α)抑制剂。Phase 1。
PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells.
In HT-29 human colon cancer xenografts, PX-478 suppresses HIF-1alpha levels and inhibits the expression of HIF-1 target genes including vascular endothelial growth factor and the glucose transporter-1. In addition, PX-478 (100 or 120 mg/kg i.p.) also shows antitumor activity including cures against several established human tumor xenografts that is related to the levels of HIF-1α. In high-fat-diet mice, PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues.
PX-478 2HCl 是一种具有口服活性的选择性hypoxia-inducible factor-1α (HIF-1α)抑制剂。PX-478 2HCl可诱导凋亡并具有抗肿瘤的活性。Phase 1。
PX-478降低缺氧和常氧环境下各种细胞系中HIF-1α蛋白水平和HIF-1反式激活，并且对蛋白质的翻译具有更显著的作用，比如缺氧环境下的 HIF-1α。 PX-478也能够增强前列腺癌PC3细胞的放射敏感性。
在HT-29人结肠癌异种移植物中，PX-478抑制HIF-1α的水平，并抑制HIF-1靶点基因的表达，包括血管内皮生长因子和葡萄糖转运体-1。此外，PX-478 (100 或120 mg/kg i.p.)也表现出抗肿瘤活性，包括治愈几种建立的与HIF-1α水平相关的人肿瘤异种移植物。在高脂饮食小鼠体内，PX-478减少它们脂肪组织中的纤维化病变和炎症浸润。
(S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | S7612 | PX-478 2HCl | 685898-44-6 | 1mg*5 | 1203.93元 |
| 2024/01/16 | S7612 | (S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
PX-478 2HCl | 685898-44-6 | 25mg | 3886.42元 |
(S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
生产厂家
685898-44-6, (S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐 相关搜索:
- 药靶配体
- 新药
- C13H20Cl4N2O3
- C13H18Cl2N2O32HCl
- 化合物PX-478 2HCL
- (S)-4-(2-氨基-2-羧乙基)-N,N-双(2-氯乙基)环己-1,3-二苯胺氧化物二盐酸盐
- 685898-44-6
- Inhibitor,Autophagy,HIFs,inhibit,PX-478,PX 478,HIF-PH,HIF/HIF Prolyl-Hydroxylase,PX478,Hypoxia-inducible factors
- ALKN004012
- (S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)cyclohexa-1,3-dienamine oxide dihydrochloride
- PX 478
DISCONTINUED
- L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1
- CS-1467
- PX-478; L-PHENYLALANINE; 4-[BIS(2-CHLOROETHYL)OXIDOAMINO]-; DIHYDROCHLORIDE; L-PHENYLALANINE; 4-[BIS(2-CHLOROETHYL)OXIDOAMINO]-; HYDROCHLORIDE (1:2).
- (S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
- 4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine dihydrochloride
- Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
- PX-478 HCl
- 4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2)
- PX478 2HCl
- PX-478 dihydrochloride
- L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)