乙酰恩格列净

乙酰恩格列净性质、用途与生产工艺

用途

制备

在氮气保护下，于500mL三颈瓶中加入干燥的THF(120mL)，冷却至-10℃，加入i-PrMgCl·LiCl的THF溶液(27.2mL，27.2mmol)和n-BuLi的正己烷溶液(21.8mL，54.4mmol)，搅拌30min。将(S)-4-溴-1-氯-2-(4-四氢呋喃-3-基氧基-苄基)苯(10.0g，27.2mmol)溶于干燥THF(10mL)中，缓慢滴加到三颈瓶中，-10℃下搅拌反应2.0h。保持-10℃下，缓慢滴加2，3，4，6-四乙酰氧基-α-D-吡喃葡萄糖溴化物(11.2g，27.2mmol)的THF(10mL)溶液，反应3.0h。反应完毕，加入6NHCl(20mL)的甲醇(100mL)溶液，升温至25℃，搅拌20.0h，用饱和NaHCO3溶液调pH至7，用EA(100mL)萃取两次，有机相依次用水(100mL)和饱和NaCl溶液(100mL)洗涤，加无水Na2SO4干燥，过滤，滤液减压浓缩至干，得淡黄色油状物III(14.3g)，即乙酰恩格列净，收率84.9％。

乙酰恩格列净 上下游产品信息

上游原料

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乙酰恩格列净 生产厂家

915095-99-7, 乙酰恩格列净 相关搜索:

• 915095-99-7
• Empagliflozin
• 原料药
• 合成材料中间体
• 柏锦生物
• 杂质对照品
• 医药原料
• 系列1
• 工厂
• 医用原料
• 医药原料
• 中间体
• 恩格列净
• 恩格列净中间体二
• C31H35ClO11
• 乙氧基恩格列净
• (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[[(3S)-四氢- 3-呋喃基]氧基]苯基]甲基]苯基]-D-山梨糖醇四
• 依帕列净杂质98
• 乙酰恩格列净 ACETOXY EMPAGLIFLOZIN
• 恩格列净中间体2(恩格列净杂质24)
• (2R、3R、4R、5S、6S)-2-(乙酰氧基甲基)-6-(4-氯-3-(4-(((S)-四氢呋喃-3-基)氧基)苄基)苯基)四氢-2H-吡喃-3,4,5-三乙酸
• 310-7
• (2R,3R,4R,5S,6S)-2-(乙酰氧甲基)-6-(4-氯-3-(4-(
• 恩格列净杂质98
• 乙酰基恩格列净
• 恩格列净中间体,乙酰恩格列净
• (1S)-1,5-脱水-2,3,4,6-四-O-乙酰基-1-C-[4-氯-3-[[4-[[(3S)-四氢呋喃-3-基]氧基]苯基]甲基]苯基]-D-葡萄糖醇(恩格列净中间体)
• D-GLUCITOL, 1,5-ANHYDRO-1-C-[4-CHLORO-3-[[4-[[(3S)-TETRAHYDRO-3-FURANYL]OXY]PHENYL]
• (S)-依帕列净乙酰化杂质
• (2R,3R,4R,5S,6S)-2-(乙酰氧甲基)-6-(4-氯-3-(4-(环丁氧基)苄基)苯基)四氢-2H-吡喃-3,4,5-三醋酸酯
• 恩格列净杂质007
• 依帕列净杂质25
• 过乙酰基依帕列净
• 5-脱水-2,3,4,6-四-O-乙酰基-1-C-[4-氯-3-[[4-[[(3S)-四氢呋喃-3-基]氧基]苯基]甲基]苯基]-D-葡萄糖醇
• (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[[(3S)-四氢-3-呋喃基]氧基]苯基]甲基]苯基]-D-山梨糖醇四乙酸酯
• 乙酰恩格列净
• (1S)-1,5-脱水-2,3,4,6-四-O-乙酰基-1-C-[4-氯-3-[[4-[[(3S)-四氢呋喃-3-基]氧基]苯基]甲基]苯基]-D-葡萄糖醇
• 915095-99-7
• Empagliflozin Tetracetyl
• (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl oxyphenyl] methyl] phenyl]-6-(acetoxymethyl) oxane-3,4 5- triyl triacetate
• (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucito
• Empagliflozin Intermediate/ Acetoxy Empagliflozin/ (1S)-1,5-Anhydro-2,3,4,6-Tetra-O-Acteyl-1-C-[4-Chloro-3-[[4-[[(3S)-Tetrahydrofu-Ran-3-Yl]Oxy]Phenyl] Methyl]Phenyl]-D-Glucitol
• Peracetyl Empagliflozin
• (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol tetraacetate
• (1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl] methyl]phenyl]-D-Glucitol
• (1S)-2,3,4,6-Tetra-O-acetyl-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydro-3-furanyloxy]benzyl}phenyl)-D-glucitol
• (S)-Empagliflozin Peracetyl ImpurityQ: What is (S)-Empagliflozin Peracetyl Impurity Q: What is the CAS Number of (S)-Empagliflozin Peracetyl Impurity Q: What is the storage condition of (S)-Empagliflozin Peracetyl Impurity Q: What are the applications of (S)-Empagliflozin Peracetyl Impurity
• (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-fur...
• (1S)-1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-Glucitol, 2,3,4,6-tetraacetate
• Peracetyl Empagliflozin Impurity
• (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucito tetraacetate
• (2R,4R)-3,4,5-Triacetyloxy-6-[4-chloro-3-[[4-(oxolan-3-yloxy)phenyl]methyl]phenyl]oxan-2-yl]methyl acetate
• (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triylTriacetate3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
• (1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-Chemicalbook[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl]methyl]phenyl]-D-Glucitol
• Empagliflozin intermediates，Acetoxy Empagliflozin
• D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-, 2,3,4,6-tetraacetate, (1S)-
• (1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl]
• Empagliflozin-10