287194-41-6
|
|
- CAS号:
- 287194-41-6
- 英文名:
- (+)-DHMEQ
- 英文别名:
- 6R)-DHMEQ;(1R,2R,6R)-DHMEQ;(+) DHMEQ,(+)DHMEQ;6R)-Dehydroxymethylepoxyquinomicin;(1R,2R,6R)-Dehydroxymethylepoxyquinomicin;2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide;Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-
- 中文名:
- 287194-41-6
- 中文别名:
- (+)-DHMEQ;化合物 T13462;2-羟基-N-[(1R,2R,6R)-2-羟基-5-氧代-7-氧杂双环[4.1.0]庚-3-烯-3-基]苯甲酰胺
- CBNumber:
- CB03146604
- 分子式:
- C13H11NO5
- 分子量:
- 261.23
- MOL File:
- 287194-41-6.mol
|
|
|
287194-41-6化学性质
-
熔点:
-
184 °C
-
|
-
沸点:
-
617.2±55.0 °C(Predicted)
-
|
-
密度:
-
1.58±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : ≥ 35 mg/mL (133.98 mM)
-
|
-
酸度系数(pKa):
-
8.43±0.30(Predicted)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
White to off-white
-
|
287194-41-6性质、用途与生产工艺
(+)-DHMEQ 是一种抗氧化转录因子 Nrf2 的激活剂。(+)-DHMEQ 是 (-)-DHMEQ 的对映体。(+)-DHMEQ 抑制 NF-kB 的活性低于(-)-DHMEQ。
(+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay. (+)-DHMEQ also increases the expression of target antioxidant proteins and cancelled reactive oxygen species (ROS)-induced cell death in a neuronal cell line. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.
287194-41-6
上下游产品信息
上游原料
下游产品
287194-41-6, 287194-41-6 相关搜索:
- 化合物 T13462
- (+)-DHMEQ
- 2-羟基-N-[(1R,2R,6R)-2-羟基-5-氧代-7-氧杂双环[4.1.0]庚-3-烯-3-基]苯甲酰胺
- 287194-41-6
- (+) DHMEQ,(+)DHMEQ
- 6R)-DHMEQ
- 6R)-Dehydroxymethylepoxyquinomicin
- Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-
- 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide
- (1R,2R,6R)-DHMEQ
- (1R,2R,6R)-Dehydroxymethylepoxyquinomicin