MELFLUFEN HYDROCHLORIDE
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- CAS号:
- 380449-54-7
- 英文名:
- Nelotanserin
- 英文别名:
- Melflufen hydrochloride;ethyl (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate
- 中文名:
- MELFLUFEN HYDROCHLORIDE
- 中文别名:
- CBNumber:
- CB03159936
- 分子式:
- C24H31Cl3FN3O3
- 分子量:
- 534.88
- MOL File:
- 380449-54-7.mol
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MELFLUFEN HYDROCHLORIDE化学性质
MELFLUFEN HYDROCHLORIDE性质、用途与生产工艺
Melflufen (Melphalan flufenamide) hydrochloride，Melphalan 的一种二肽前体药物，是一种烷基化剂。Melflufen hydrochloride 对多发性骨髓瘤细胞具有抗肿瘤活性，并抑制血管生成。Melflufen hydrochloride 对骨髓瘤细胞 DNA 不可逆损伤及细胞毒作用。
Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner.
Melflufen hydrochloride induces apoptosis in MM.1S cells.
Melflufen hydrochloride also is a potent activator of exosome secretion.
Cell Viability Assay
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Cell Line:
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Multiple myeloma cells: MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6 cells
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Concentration:
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0.5, 1, 3, 5, 10 μM
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Incubation Time:
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24 hours
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Result:
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A significant concentration-dependent decrease in viability of all cell lines was observed.
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Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model.
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Animal Model:
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CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model)
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Dosage:
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3 mg/kg
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Administration:
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1.v.; twice-weekly for two weeks
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Result:
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Significantly inhibited MM tumor growth and prolonged survival of mice.
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MELFLUFEN HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-105019A | Melflufen hydrochloride | | 1 mg | 1909元 |
| 2024/04/30 | HY-105019A | MELFLUFEN HYDROCHLORIDE
Melflufen hydrochloride | 380449-54-7 | 5mg | 4200元 |
MELFLUFEN HYDROCHLORIDE
生产厂家
380449-54-7, MELFLUFEN HYDROCHLORIDE 相关搜索:
- C24H31Cl3FN3O3
- 380449-54-7
- Melflufen hydrochloride
- ethyl (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate