1-(2-噻唑基偶氮)-2-萘酚
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- CAS号:
- 1147-56-4
- 英文名:
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- 英文别名:
- TAN;ERGi-USU;NSC139021;Nitrilotantalum(III);NSC139021 (ERGi-USU);ERGi-USU
(NSC139021);1-(2’-Thiazolylazo)-β-naphtho;1-(2-THIAZOLYLAZO)-2-NAPHTHOL;1-(thiazol-2-ylazo)-2-naphthol;1-(2'-Thiazolylazo)-β-naphthol
- 中文名:
- 1-(2-噻唑基偶氮)-2-萘酚
- 中文别名:
- 1-(2-联氮噻吩)-2-萘酚;1-(2-噻唑偶氮)-2-萘酚;1-(2’-噻唑偶氮)-2-萘酚;2-(2-羟基-1-萘偶氮)噻唑;1-(2-噻唑基偶氮)-2-萘酚;2-(2-羟基-1-萘基偶氮)噻唑;1-(2'-噻唑基偶氮)-2-萘酚;1-(2-联氮噻吩)-2-萘酚,98%;TAN [=1-(2-噻唑偶氮)-2-萘酚;1-(2-噻唑偶氮)-2-萘酚[过渡金属类用分光光度试剂]
- CBNumber:
- CB0321974
- 分子式:
- C13H9N3OS
- 分子量:
- 255.3
- MOL File:
- 1147-56-4.mol
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1-(2-噻唑基偶氮)-2-萘酚性质、用途与生产工艺
NSC139021 (ERGi-USU) 是ERG阳性癌细胞生长的高度选择性抑制剂，抑制不同细胞系的 IC50 值为 30 到400 nM。
IC50: 30 to 400 nM (ERG-positive cancer cells)
NSC139021 selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines. The IC
50
of NSC139021 for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM. Combination of NSC139021 with enzalutamide shows additive effects in inhibiting growth of VCaP cells. A screen of kinases reveal that NSC139021 directly bound the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature.
NSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. .
1-(2-噻唑基偶氮)-2-萘酚
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-112158 | 1-(2-噻唑基偶氮)-2-萘酚
NSC139021 | 1147-56-4 | 100mg | 500元 |
| 2024/01/25 | HY-112158 | 1-(2-噻唑基偶氮)-2-萘酚
NSC139021 | 1147-56-4 | 10mM * 1mLin DMSO | 550元 |
1147-56-4, 1-(2-噻唑基偶氮)-2-萘酚 相关搜索:
- Naphthylazo Compounds
- Chelating Reagents
- Azo Compounds
- Analytical Chemistry
- 试剂和补充物
- Spectroscopy Reagents
- Chelating Reagents
- Naphthylazo Compounds
- Azo Compounds
- Analytical Reagents
- Analytical Chromatography Product Catalog
- IR/UV/ VIS
- 147-56-4
- TAN [=1-(2-噻唑偶氮)-2-萘酚
- TAN [=1-(2-噻唑偶氮)-2-萘酚] [过渡金属用分光光度试剂
- 1-(2-联氮噻吩)-2-萘酚,98%
- 1-(2-噻唑偶氮)-2-萘酚[过渡金属类用分光光度试剂]
- 2-(2-羟基-1-萘偶氮)噻唑
- TAN[=1-(2-噻唑偶氮)-2-萘酚](>99.0%(T))
- TAN[=1-(2-噻唑偶氮)-2-萘酚][过渡金属类用分光光度试剂]
- 1-(2’-噻唑偶氮)-2-萘酚
- 1-(2-联氮噻吩)-2-萘酚
- 2-(2-羟基-1-萘基偶氮)噻唑
- 1-(2'-噻唑基偶氮)-2-萘酚
- 1-(2-噻唑偶氮)-2-萘酚
- 1-(2-噻唑基偶氮)-2-萘酚
- 1147-56-4
- inhibit,NSC 139021,NSC-139021,NSC139021,Inhibitor
- ERGi-USU
- 1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol
- (1Z)-1-(2-thiazolylhydrazinylidene)-2-naphthalenone
- ERGi-USU
(NSC139021)
- NSC139021
- TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]>
- 2-Naphthalenol, 1-[2-(2-thiazolyl)diazenyl]-
- NSC139021 (ERGi-USU)
- 1-(2'-Thiazolylazo)-β-naphthol
- 1-(thiazol-2-ylazo)-2-naphthol
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- 2-(2-HYDROXY-1-NAPHTHYLAZO)THIAZOLE
- 1-(2-thiazolylazo)-2-Naphthalenol
- 1-(2-thiazolylazo)-2-naphthaleno
- 1-(2’-Thiazolylazo)-β-naphtho
- 1-(1,3-Thiazolyl-2-azo)-2-naphthol
- 1-(2-Thiazolylazo)-2-naphthol,2-(2-Hydroxy-1-naphthylazo)thiazole, TAN
- (E)-1-(thiazol-2-yldiazenyl)naphthalen-2-ol
- TAN [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals]
- TAN [=1-(2-Thiazolylazo)-2-naphthol]
- 1-[(Thiazole-2-yl)azo]-2-naphthol
- 1-(Thiazole-2-ylazo)naphthalene-2-ol
- 1-(Thiazole-2-ylazo)-2-naphthol
- Nitrilotantalum(III)
- 2-(2-Hydroxy-1-naphthylazo)thiazole, TAN
- TAN