盐酸普奈洛尔
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- CAS号:
- 13071-11-9
- 英文名:
- (R)-(+)-PROPRANOLOL
- 英文别名:
- AY 20694;ICI 47319;R-PROPANOLOL;d-Anapriline;R-PROPRANOLOL;(+)-Anapriline;(R)-(+)-PROPRANOLOL;R-(+)-PROPANOLOL HCL;expropranololhydrochloride;d-Propranolol hydrochloride
- 中文名:
- 盐酸普奈洛尔
- 中文别名:
- 盐酸普奈洛尔;(R)-盐酸普萘洛尔;(R)-(+)-普奈洛尔 盐酸盐;(R)-(+)-普奈洛尔;(R)-1-(异丙基氨基)-3-(1-萘氧基)-2-丙醇盐酸;(R)-1-(异丙基氨基)-3-(1-萘氧基)-2-丙醇 盐酸盐
- CBNumber:
- CB0327608
- 分子式:
- C16H21NO2.ClH
- 分子量:
- 295.81
- MOL File:
- 13071-11-9.mol
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盐酸普奈洛尔化学性质
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熔点:
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196-198 °C(lit.)
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储存条件:
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Store below +30°C.
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溶解度:
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ethanol: 10 mg/mL
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形态:
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Solid
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颜色:
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White to Off-White
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水溶解性:
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Soluble to 100 mM in water
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BRN:
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5780490
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CAS 数据库:
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13071-11-9(CAS DataBase Reference)
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盐酸普奈洛尔性质、用途与生产工艺
盐酸普萘洛尔为白色结晶性粉末,溶于水。分子结构中有一个手性原子,S(—)异构体活性强,药品为外消旋体。其为非选择性β-受体阻断药,阻断心肌的β受体,对β1和β2受体均有拮抗作用。
盐酸普奈洛尔为非选择性β-受体阻断药,阻断心肌的β受体,对β1和β2受体均有拮抗作用。减慢心率,,抑制心脏收缩力与传导、循环血量减少、心肌耗氧量降低。
盐酸普奈洛尔临床主要用于治疗多种原因所致的心律失常,也可用于心绞痛高血压嗜铬细胞瘤(手术前准备)等。由于拮抗β2受体可引起支气管痉挛和哮喘,故本品禁用于支气管哮喘的病人。
(R)-Propranolol hydrochloride 是抗肾上腺素受体 (β-adrenoceptor) 拮抗剂普萘洛尔 (HY-B0573) 的活性较低的对映体。Propranolol 是一种非选择性的 β-adrenergic receptor (βAR) 拮抗剂,对 β1AR 和 β2AR 具有高亲和力,Ki 值分别为 1.8 nM 和 0.8 nM。
Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol is 0.09 mg/kg whereas that of (+)-propranolol is 4.2 mg/kg.Both isomers of propranolol are capable of reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs. The dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species.(R)-Propranolol hydrochloride (10 mg/kg) has no antagonistic activity in rats, the cardiac responses to isoprenaline of rat can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation.
用途
The R-enantiomer of Propranolol (P831800). β鈭扐drenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
盐酸普奈洛尔
上下游产品信息
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-A0295 | 盐酸普奈洛尔 (R)-Propranolol hydrochloride | 13071-11-9 | 100mg | 900元 |
盐酸普奈洛尔
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13071-11-9, 盐酸普奈洛尔 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
- Amines
- 生化试剂
- 合成
- 氨基酸衍生化合物
- 药物杂质
- 五官科用药
- 原料药
- 医药与生物化工
- Chiral Building Blocks
- Asymmetric Synthesis
- Amino Alcohols
- Organic Building Blocks
- C10H7OCH2CHOHCH2NHCHCH32HCl
- C16H21NOSHCl
- (R)-(+)-普奈洛尔
- (R)-1-(异丙基氨基)-3-(1-萘氧基)-2-丙醇盐酸
- (R)-盐酸普萘洛尔
- (R)-1-(异丙基氨基)-3-(1-萘氧基)-2-丙醇 盐酸盐
- (R)-(+)-普奈洛尔 盐酸盐
- 盐酸普奈洛尔
- 13071-11-9
- Flumiclorac-pentyl Impurity 11
- Inhibitor,enantiomer,Beta Receptor,(R)-Propranolol,Adrenergic Receptor,β-adrenoceptor,cardiac arrhythmias,(R)Propranolol hydrochloride,(R) Propranolol hydrochloride,inhibit
- expropranololhydrochloride
- (R)-(+)-PROPANOLOL HYDROCHLORIDE FOR SYN
- (2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-propanol hydrochloride
- (R)-1-(isopropylaMino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
- (R)-(+)-PROPANOLOL HYDROCHLORIDE 99+%
- (R)-[2-hydroxy-3-(naphthyloxy)propyl]isopropylammonium chloride
- (R)-(+)-Propranolol hydrochloride,(R)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
- Dexpropranolol hydrochloride
- (R)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
- (R)-(+)-1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
- (R)-(+)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE
- (R)-PROPRANOLOL HYDROCHLORIDE
- (R)-(+)-PROPRANOLOL HYDROCHLORIDE
- R-PROPRANOLOL
- (R)-(+)-PROPRANOLOL
- (R)-(+)-PROPANOLOL HYDROCHLORIDE
- R-(+)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride
- ICI 47319
- d-Propranolol hydrochloride
- d-Anapriline
- AY 20694
- 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (R)-
- 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2R)- (9CI)
- 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, hydrochloride, (+)- (8CI)
- (+)-Anapriline
- 2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)-, hydrochloride, (2R)-
- 2R-(+)-PROPANOLOL HYDROCHLORIDE
- (R)-(+)-Propanolol hydrochloride for synthesis
- 2R-(+)-Propanolol hydrochloride≥ 95% (GCMS)
- R-(+)-PROPANOLOL HCL
- R-PROPANOLOL