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CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
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- CAS号:
- 127060-75-7
- 英文名:
- CGP 42112
- 英文别名:
- CGP 42112;CGP-42112A;CGP42112A, CGP42112;CGP-42112
(CGP42112;ANGIOTENSIN II ANTAGONIST;ANGIOTENSIN II RECEPTOR LIGAND;NIC-TYR-LYS(Z-ARG)-HIS-PRO-ILE;CGP-42112A >=95%, synthetic, solid;NICOTINOYL-TYR-LYS(CBZ-ARG)-HIS-PRO-ILE;NICOTINOYL-TYR-LYS(Z-ARG)-HIS-PRO-ILE-OH
- 中文名:
- CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
- 中文别名:
- 化合物 T14939;CGP-42112游离态;AT2激动剂多肽CGP42112A;NICOTINOYL-TYR-LYS(CBA-ARG)-HIS-PRO-ILE-OH;CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE;(2S,3S)-2-((S)-1-((5S,12S,15S)-15-((1H-咪唑-5-基)甲基)-5-(3-胍丙基)-12-((S)-3-(4-羟基苯基)-2-(烟酰胺基)丙胺基)-3,6,13-三氧代-1-苯基-2-氧代-4,7,14-三氮杂十六烷-16-酰基)吡咯烷-2-甲酰胺)-3-甲基戊酸
- CBNumber:
- CB0334084
- 分子式:
- C52H69N13O11
- 分子量:
- 1052.18
- MOL File:
- 127060-75-7.mol
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CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE化学性质
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密度:
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1.39±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO:350.0(Max Conc. mg/mL);332.64(Max Conc. mM)
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形态:
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solid
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酸度系数(pKa):
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3.72±0.22(Predicted)
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颜色:
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white
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水溶解性:
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Soluble to 1 mg/ml in water
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BRN:
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8184948
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CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE性质、用途与生产工艺
CGP-42112(CGP-42112A)是血管紧张素受体AT2激动剂。
CGP-42112 (≥1 nM) significantly inhibits cGMP production from the basal value. CGP-42112 (≥1 nM) significantly inhibits TH-enzyme activity from the basal value. These inhibitory effects of CGP-42112 on TH-enzyme activity and-cGMP production are abolished by PD123319 (AT(2)-R antagonist) while CV-11974 (AT(1)-R antagonist) is ineffective.
[
125
I]CGP-42112 binds selectively to the AT2 angiotensin II receptor subtype. [
125
I]CGP-42112 binds with higher affinity in the brain than in the adrenal. beta-Mercaptoethanol enhanced [
125
I]CGP-42112 binding in the brain, but does not alter its binding in the adrenal.
[
125
I]CGP-42112 binds with high affinity (Kd = 0.07-0.3 nM, depending on the area studied). [
125
I]CGP-42112 binding is selective for AT2 receptors, as determined by lack of competition with the AT1 ligand losartan, and competition by the AT2 ligands PD 123177 and unlabeled CGP-42112 and the non-selective peptides Ang II and angiotensin III (Ang III).
Intravenous infusions of CGP-42112 (0.1 and 1 mg kg-1 min-1) and PD 123319 (0.36 and 1 mg kg-1 min-1) shifted the upper limit of CBF autoregulation toward higher blood pressures without affecting baseline CBF.
CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-12405 | CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE CGP-42112 | 127060-75-7 | 1mg | 1300元 |
2024/01/25 | HY-12405 | CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE CGP-42112 | 127060-75-7 | 5mg | 4460元 |
CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
生产厂家
127060-75-7, CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE 相关搜索:
- 多肽
- 目录肽
- Peptides
- BioChemical
- Amino Acids and Peptides
- Angiotensins
- Biochemicals and Reagents
- C52H69N13O11
- (2S,3S)-2-((S)-1-((5S,12S,15S)-15-((1H-咪唑-5-基)甲基)-5-(3-胍丙基)-12-((S)-3-(4-羟基苯基)-2-(烟酰胺基)丙胺基)-3,6,13-三氧代-1-苯基-2-氧代-4,7,14-三氮杂十六烷-16-酰基)吡咯烷-2-甲酰胺)-3-甲基戊酸
- AT2激动剂多肽CGP42112A
- 化合物 T14939
- NICOTINOYL-TYR-LYS(CBA-ARG)-HIS-PRO-ILE-OH
- CGP-42112游离态
- CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
- 127060-75-7
- (2S,3S)-2-((S)-1-((5S,12S,15S)-15-((1H-Imidazol-5-yl)methyl)-5-(3-guanidinopropyl)-12-((S)-3-(4-hydroxyphenyl)-2-(nicotinamido)propanamido)-3,6,13-trioxo-1-phenyl-2-oxa-4,7,14-triazahexadecan-16-oyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid
- Angiotensin II Receptor Ligand Nicotinoyl-Tyr-Lys(Z-Arg)-His-Pro-Ile-OH
- NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
- CGP-42112A >=95%, synthetic, solid
- L-Isoleucine, N-(3-pyridinylcarbonyl)-L-tyrosyl-N6-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-L-lysyl-L-histidyl-L-prolyl-
- CGP-42112
(CGP42112
- CGP42112;CGP 42112;CGP-42112A;CGP42112A;CGP 42112A
- CGP42112A, CGP42112
- CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
- N6-[[(Phenylmethoxy)carbonyl]-L-Arg-]-N2-[[(pyridin-3-yl)carbonyl]-L-Tyr-]-L-Lys-L-His-L-Pro-L-Ile-OH
- nα-nicotinoyl-tyr-(nα-cbz-arg)-lys-his-pro-ile
- N-NICOTINOYL-TYR-N-EPSILON(NA-CBZ-ARG)-L YS-HIS-PRO
- CGP-42112A >98% SYNTHETIC (POTENTANGIOTE NSIN II TYPE A
- ANGIOTENSIN II RECEPTOR LIGAND
- ANGIOTENSIN II ANTAGONIST
- CGP-42112A
- CGP 42112
- NIC-TYR-LYS(Z-ARG)-HIS-PRO-ILE
- NICOTINOYL-TYR-LYS(Z-ARG)-HIS-PRO-ILE-OH
- NICOTINOYL-TYR-LYS(CBZ-ARG)-HIS-PRO-ILE
- N-ALPHA-NICOTINOYL-TYR-(N-ALPHA-CBZ-ARG)-LYS-HIS-PRO-ILE-OH
- N-ALPHA-NICOTINOYL-TYR-LYS(N-ALPHA-CBZ-ARG)-HIS-PRO-ILE
- [N-ALPHA-(NICOTINOYL-L-TYROSYL)-N-EPSILON-(N-ALPHA-Z-L-ARGINYL)-L-LYSYL]-L HISTIDYL-L-PROLYL-L-ISOLEUCINE