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(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
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- CAS号:
- 127910-31-0
- 英文名:
- (E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
- 英文别名:
- CGP 37849;CGP 37849;CGP-37849;CGP37849;dl-2-amino-4-methyl-5-phosphono-3-*pentenoic acid;(E)-2-Amino-4-methyl-5-phosphonopent-3-enoic acid;(3E)-2-Amino-4-methyl-5-phosphono-3-pentanoic acid;(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID;3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-;(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
- 中文名:
- (E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
- 中文别名:
- 化合物 T7720;(E)-2-氨基-4-甲基-5-膦酰基-3-戊烯酸
- CBNumber:
- CB0334453
- 分子式:
- C6H12NO5P
- 分子量:
- 209.14
- MOL File:
- 127910-31-0.mol
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(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID化学性质
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沸点:
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523.1±60.0 °C(Predicted)
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密度:
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1.506±0.06 g/cm3(Predicted)
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储存条件:
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Desiccate at +4°C
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溶解度:
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H2O: ≥2mg/mL (warmed)
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形态:
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powder
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酸度系数(pKa):
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1.83±0.10(Predicted)
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颜色:
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white to beige
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(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID性质、用途与生产工艺
CGP 37849 是一种有效的竞争性口服活性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂。CGP 37849 是啮齿动物的抗惊厥药,具有抗抑郁和抗焦虑作用。
In the hippocampal slice in vitro, CGP 37849 selectively and reversibly antagonizes NMDA-evoked increases in CA1 pyramidal cell firing rate. In slices bathed in medium containing low Mg
2+
levels, concentrations of CGP 37849 up to 10 μM suppresses burst firing evoked in CA1 neurones by stimulation of Schaffer collateral-commissural fibres without affecting the magnitude of the initial population spike.
CGP 37849 potently (
K
i
of 220 nM) and competitively inhibits NMDA-sensitive l-[
3
H]-glutamate binding to postsynaptic density (PSD) fractins from rat brain. CGP 37849 inhibits the binding of the selective NMDA receptor antagonist, [
3
H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP), with a
K
i
of 35 nM.
In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurones induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate.
Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an
ED
50
of 21 mg/kg.
(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-107702 | (E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID CGP 37849 | 127910-31-0 | 1mg | 2000元 |
2024/01/25 | HY-107702 | (E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID CGP 37849 | 127910-31-0 | 5mg | 6500元 |
(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
生产厂家
127910-31-0, (E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID 相关搜索:
- Glutamate
- Glutamate receptor
- C6H12NO5P
- 化合物 T7720
- (E)-2-氨基-4-甲基-5-膦酰基-3-戊烯酸
- 127910-31-0
- 3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-
- CGP 37849;CGP-37849;CGP37849
- (E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
- (E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
- CGP 37849
- (E)-2-Amino-4-methyl-5-phosphonopent-3-enoic acid
- (3E)-2-Amino-4-methyl-5-phosphono-3-pentanoic acid
- dl-2-amino-4-methyl-5-phosphono-3-*pentenoic acid