盐酸丁双胍
|
|
|
- CAS号:
- 1190-53-0
- 英文名:
- BuforMin Hydrochloride
- 英文别名:
- BUTYL-BIGUANIDE HYDROCHLORIDE;Andere;Adebit;TideMol;Biforon;Sindiatil;PanforMin;Ziavetine;NSC528218;Aids126511
- 中文名:
- 盐酸丁双胍
- 中文别名:
- 盐酸丁福明;盐酸丁二胍;盐酸丁双胍;丁福明盐酸盐;丁双胍盐酸盐;丁二胍盐酸盐;盐酸丁双胍 标准品;N-丁基双胍盐酸盐;盐酸丁二胍/盐酸丁福明;正丁基亚胺基二碳亚胺二酰胺盐酸盐
- CBNumber:
- CB0407151
- 分子式:
- C6H16ClN5
- 分子量:
- 193.68
- MOL File:
- 1190-53-0.mol
|
|
|
盐酸丁双胍化学性质
-
熔点:
-
177-179?C
-
|
-
储存条件:
-
Inert atmosphere,Store in freezer, under -20°C
-
|
-
溶解度:
-
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
White to Off-White
-
|
-
稳定性:
-
Hygroscopic
-
|
-
CAS 数据库:
-
1190-53-0
-
|
盐酸丁双胍性质、用途与生产工艺
Buformin hydrochloride (1-Butylbiguanide hydrochloride) 是一种有效的 AMPK 活化剂，也是具有口服活性的双胍类降血糖试剂 (antidiabetic agent)。Buformin 降低肝糖异生并降低血糖生成。Buformin 也具有抗癌活性，可以应用于癌症研究，如宫颈癌、乳腺癌等。
Buformin hydrochloride (0-10 mM; 5 days) inhibits SKBR3 and BT474 cells growth as a concentration-dependent manner, exhibits IC
50
values of 246.7 μM and 98.6 μM for erbB-2-overexpressing SKBR3 and BT474 cells, respectively.Buformin hydrochloride (0-3 mM; 48 hours) increases the percentage of cells in G0/G1 phase and reduced the percentage of cells in S phase, especially in the SKBR3 cells.Buformin hydrochloride (0-3 mM; 24 hours) suppresses RTK activation, including erbB-2 and IGF1R signaling downstream, and Akt activation/phosphorylation is inhibited in both SKBR3 and BT474 cells.
Cell Viability Assay
|
Cell Line:
|
ErbB-2-overexpressing SKBR3 and BT474 cells
|
|
Concentration:
|
0 μM, 1 μM, 3 μM, 10 μM, 30 μM, 100 μM, 300 μM, 1, 3, or 10 mM
|
|
Incubation Time:
|
5 days
|
|
Result:
|
Reduced cell viability in erbB-2-overexpressing breast cells.
|
Cell Cycle Analysis
|
Cell Line:
|
ErbB-2-overexpressing SKBR3 and BT474 cells
|
|
Concentration:
|
0.5 mM; 1 mM; 3 mM
|
|
Incubation Time:
|
48 hours
|
|
Result:
|
Increased cells arresting in G0/G1 phase.
|
Western Blot Analysis
|
Cell Line:
|
ErbB-2-overexpressing SKBR3 and BT474 cells
|
|
Concentration:
|
0 mM, 0.1 mM, 0.3 mM, 1 mM, or 3 mM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Decreased p-AMPK, p-p706S, p-ERK1/2 expression in a concentration-dependent manner.
|
Buformin hydrochloride (oral administation; 7.6 mmol/kg of chow; 7 days) exhibits significantly reduced tumor volumes and weights, and hinders mammary morphogenesis and proliferation in MMTV-erbB-2 transgenic mice.
|
Animal Model:
|
Female MMTV-erbB-2 transgenic mice
|
|
Dosage:
|
7.6 mmol/kg
|
|
Administration:
|
Oral administation; 7 days
|
|
Result:
|
Inhibited mammary syngeneic tumor growth in MMTV-erbB-2 transgenic mice.
|
类别
有毒物品
毒性分级
高毒
急性毒性
口服-大鼠 LD50: 320 毫克/公斤; 口服-小鼠 LD50: 380 毫克/公斤
可燃性危险特性
热分解排出有毒氮氧化物和氯化氢烟雾
储运特性
库房通风低温干燥; 与食品原料类分开存放
灭火剂
水,干粉、干砂、二氧化碳、泡沫、1211灭火剂
盐酸丁双胍
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-B2099A | Buformin hydrochloride | | 50 mg | 800元 |
| 2024/01/25 | HY-B2099A | 盐酸丁双胍
Buformin hydrochloride | 1190-53-0 | 100mg | 1200元 |
盐酸丁双胍
生产厂家
全球有 97家供应商
盐酸丁双胍国内生产厂家
1190-53-0, 盐酸丁双胍 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Amines
- 药靶配体
- 原料药-激素及调节内分泌功能类药
- 对照品
- C6H15N5HCl
- C6H16ClN5
- 丁二胍盐酸盐
- 丁DIGUANIDINE HCL
- N-丁基双胍盐酸盐
- BUFORMIN HYDROCHLORIDE 丁双胍盐酸盐
- 甲醇中盐酸丁二胍溶液,100ΜG/ML
- 盐酸丁福明BUFORMIN HYDROCHLORIDE
- 盐酸丁福明, 盐酸丁二胍, 盐酸丁双胍
- 丁双胍盐酸盐
- 盐酸丁双胍 标准品
- 正丁基亚胺基二碳亚胺二酰胺盐酸盐
- 丁福明盐酸盐
- 盐酸丁福明
- 盐酸丁二胍
- 盐酸丁二胍/盐酸丁福明
- 盐酸丁双胍
- 1190-53-0
- Buformin hydrochloride >=98% (HPLC)
- N-Butylbiguanide Hydrochloride v
- agent,Type II diabete,inhibit,Buformin hydrochloride,Inhibitor,SKBR3,cervical cancer,breast cancer,AMPK,biguanide analog,BT474,1-Butylbiguanide,antidiabetic,AMP-activated protein kinase,Buformin
- BUTYL-BIGUANIDE HYDROCHLORIDE
- NSC-528218
- NSC528218
- NSC 528218
- Imidodicarbonimidic diamide, N-butyl-, hydrochloride (1:1)
- Buformin HclQ: What is
Buformin Hcl Q: What is the CAS Number of
Buformin Hcl Q: What is the storage condition of
Buformin Hcl Q: What are the applications of
Buformin Hcl
- BuforMin Hydrochloride USP/EP/BP
- Buformin hydrochloride solution in Methanol，100μg/mL
- buformin hydrochloride
- N-butylimidodicarbonimidic diamide hydrochloride
- Dibetos-B (TN)
- Buformin hydrochloride (JAN)
- 1-Butyl-3-carbamimidoyl-guanidine hydrochloride
- n-butylbiguanideHCl
- 1-butylbiguanide monohydrochloride
- N-BUTYL BIGUANIDE HYDROCHLORIDE
- BUFORMINE HYDROCHLORIDE
- BUFORMINE HCL
- Biguanide, 1-butyl-, hydrochloride
- Biforon
- Andere
- Aids-126511
- Aids126511
- Adebit
- Ziavetine
- TideMol
- Sindiatil
- PanforMin
- N-ButylidodicarboniMidic DiaMide Hydrochloride
- 1-Butylbiguanide Hydrochloride
- 1-Butylbigyanidine hydrochloride