替尼泊甙
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- CAS号:
- 29767-20-2
- 英文名:
- Teniposide
- 英文别名:
- etp;vehem;vm-26;Vumon;Eniposide;nsc122819;Teniposid;Tenoposide;nsc-122819;TENIPOSIDE
- 中文名:
- 替尼泊甙
- 中文别名:
- 替尼泊苷;替尼泊甙;鬼臼噻吩苷;足叶噻吩昔;替尼泊苷杂质2;替尼泊甙,替尼泊苷;替尼泊甙(对照品);替尼泊甙,替尼泊苷(标准品);2'-脱氧-2'-氟喜树碱核苷;4'-去甲基表鬼臼毒素-BETA-D-噻吩亚甲基吡喃葡萄糖甙
- CBNumber:
- CB0455475
- 分子式:
- C32H32O13S
- 分子量:
- 656.65
- MOL File:
- 29767-20-2.mol
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替尼泊甙化学性质
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熔点:
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244-247°C
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沸点:
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650.86°C (rough estimate)
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比旋光度:
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D20 -107° (9:1 chloroform/methanol)
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密度:
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1.2568 (rough estimate)
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折射率:
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1.5530 (estimate)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系数(pKa):
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10.13(at 25℃)
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形态:
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powder
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颜色:
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white to beige
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旋光性 (optical activity):
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[α]/D -100 to -115°, c = 1 in chloroform/methanol (9:1)
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最大波长(λmax):
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283nm(MeOH)(lit.)
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Merck:
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14,9145
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稳定性:
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Hygroscopic
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CAS 数据库:
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29767-20-2(CAS DataBase Reference)
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(IARC)致癌物分类:
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2A (Vol. 76) 2000
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替尼泊甙 MSDS
[5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
替尼泊甙 化学药品说明书
替尼泊苷|药物应用信息
替尼泊甙注射液
替尼泊甙性质、用途与生产工艺
替尼泊苷为鬼臼毒素的半合成衍生物,为周期特异性细胞毒药物,作用于细胞周期S后期或G
2前期的细胞,通过阻止细胞进入有丝分裂而起作用。本品也引起DNA单链断裂,引起断裂数为Vp-16的5倍,作用机理是抑制Ⅰ型拓扑异构酶。主要代谢物为羟基酸、苦味酸内酯衍生物及它的糖苷基,其中糖基对DNA有活性。39.5%从尿中排泄,43.1%从粪便排出。
在一定剂量范围内,替尼泊甙药代动力学参数呈线性,药物在体内不发生蓄积。静脉注射后,药物从中央室1相清除,分布相半衰期约1小时。在体内与蛋白的结合率高。替尼泊甙能通过血脑屏障,在脑脊液的浓度低于血药浓度。药物的肾脏清除率仅占总清除率的10%。替尼泊甙清除半衰期约为6~20小时。
替尼泊苷临床主要用于白血病、恶性淋巴瘤、神经母细胞瘤、脑瘤、何杰金病、膀胱癌、小细胞肺癌等。
替尼泊苷主要毒副反应为骨髓抑制,表现为血小板减少,白细胞下降则较轻。常见的还有恶心、呕吐、脱发、腹泻、腹痛、皮疹、发热和静脉炎等。偶见转氨酶升高。也有报道,使用本品可能发生过敏反应,引起支气管痉挛、皮肤潮红、荨麻疹、呼吸困难及低血压等,罕见口炎、头痛及精神混乱现象。
用途
用于白血病、恶性淋巴瘤、神经母细胞瘤、膀胱癌和小细胞肺癌。
用途
一种鬼臼毒素的半合成衍生物,具有抗肿瘤活性。是拓扑异构酶II的抑制剂。Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle.
替尼泊甙
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-13761 | Teniposide | | 5 mg | 216元 |
2024/01/25 | HY-13761 | Teniposide | | 10 mg | 347元 |
替尼泊甙
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29767-20-2, 替尼泊甙 相关搜索:
- 29767-20-2
- Active Pharmaceutical Ingredients
- Inhibitors
- VUMON
- API
- Isotope Labelled Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Chiral Reagents
- Carbohydrates & Derivatives
- 生化试剂
- 原料药
- 医药
- 医药原料
- 抗癌药
- 科研试剂
- 小分子抑制剂
- 抗肿瘤类药物及免疫抑制剂
- 小分子抑制剂,天然产物
- C32H29D3O13S
- C32H32O13S
- 29767-20-7
- 29707-20-2
- 2'-脱氧-2'-氟喜树碱核苷
- 替尼泊甙(对照品)
- 替尼泊苷杂质2
- (5R,5AR,8AR,9S)-9-(((2R,4AR,6R,7R,8R,8AS)-7,8-二羟基-2-(噻吩-2-基)六氢吡喃并[3,2-D][1,3]二氧杂环己烯-6-基)氧基)-5-(4-羟基-3,5-二甲氧基苯基)-5,5A,8A,9-四氢呋喃并[3',4':6,7]萘并[2,3-D][1,3]二氧杂环戊烯-6(8H)-酮
- 替尼泊甙,替尼泊苷(标准品)
- 替尼泊甙,替尼泊苷
- 4'-去甲基表鬼臼毒素-BETA-D-噻吩亚甲基吡喃葡萄糖甙
- 鬼臼噻吩苷
- 替尼泊苷
- 足叶噻吩昔
- 替尼泊甙
- 29767-20-2
- Teniposide (200 mg) (PLANNED TO BE DISCONTINUED)
- Teniposid
- (5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-(thiophen-2-yl)hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
- etp
- Methylguanidoacetic acid monohydrate
- Teniposide (1643736)
- Teniposide Impurity 2
- Teniposide USP/EP/BP
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-
- eniposide, Vumon, VM-26
- 4'-Dimethylepipodophyllotoxin-9-(4,6-O-2-thenylidene)-b-D-glucopyranoside
- Vumon
- Pipodophyllotoxin VM 26
- Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)-oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))
- 4'-Demethyl 1-O-(4,6-O,O-(2-thenylidene)-beta-D-glucopyranosyl)epipodophyllotoxin
- [5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-b-D-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-
- vm-26
- vehem
- TENIPOSIDE
- nsc-122819
- nsc122819