PF-06826647
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- CAS号:
- 2127109-84-4
- 英文名:
- (1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutanecarbonitrile
- 英文别名:
- Tyk2-IN-8;PF6826647;PF 6826647;PF-6826647;PF-06826647;Ropsacitinib;PF-06826647( Tyk2-IN-8);Ropsacitinib (PF-06826647;Cyclobutaneacetonitrile, 3-cyano-1-[4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl]-, trans-;cis-3-(Cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutanecarbonitrile
- 中文名:
- PF-06826647
- 中文别名:
- 化合物 T13237L;化合物ROPSACITINIB;PF-06826647(PF-06826647);反式-3-(氰基甲基)-3-(4-(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-A]吡嗪-4-基)-1H-吡唑-1-基)环丁烷腈;(1R,3R)-3-(氰甲基)-3-(4-(6-(1-甲基-1H-吡唑-4-基)吡唑[1,5-A]吡嗪-4-基)-1H-吡唑-1-基)环丁腈
- CBNumber:
- CB04923831
- 分子式:
- C20H17N9
- 分子量:
- 383.41
- MOL File:
- 2127109-84-4.mol
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PF-06826647化学性质
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密度:
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1.46±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 16.67 mg/mL (43.48 mM)
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酸度系数(pKa):
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0.98±0.19(Predicted)
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PF-06826647性质、用途与生产工艺
PF-06826647 (Tyk2-IN-8, compound 10) 是一种选择性的 tyrosine kinase 2 (TYK2) 的口服抑制剂，IC50值为17 nM，可与TYK2催化活性JH1结构域结合。PF-06826647 (Tyk2-IN-8, compound 10) 也可抑制 JAK1 和 JAK2，对应的IC50值分别为383 nM和74 nM。PF-06826647 (Tyk2-IN-8, compound 10) 可用于治疗牛皮癣(PSO)。
| Target | Value |
TYK2
(Cell-free assay)
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17 nM
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JAK2
(Cell-free assay)
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74 nM
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JAK1
(Cell-free assay)
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383 nM
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PF-06826647
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-144031S | Tyk2-IN-8 | | 1 mg | 8100元 |
| 2024/01/16 | S9676 | PF-06826647
PF-06826647 | 2127109-84-4 | 5mg | 5700.13元 |
2127109-84-4, PF-06826647 相关搜索:
- 化工试剂
- 抑制剂
- 化合物ROPSACITINIB
- 反式-3-(氰基甲基)-3-(4-(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-A]吡嗪-4-基)-1H-吡唑-1-基)环丁烷腈
- 化合物 T13237L
- (1R,3R)-3-(氰甲基)-3-(4-(6-(1-甲基-1H-吡唑-4-基)吡唑[1,5-A]吡嗪-4-基)-1H-吡唑-1-基)环丁腈
- PF-06826647(PF-06826647)
- 2127109-84-4
- PF-6826647
- PF6826647
- PF 6826647
- cis-3-(Cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutanecarbonitrile
- Ropsacitinib
- trans-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutanecarbonitrile
- Ropsacitinib (PF-06826647
- PF-06826647( Tyk2-IN-8)
- Cyclobutaneacetonitrile, 3-cyano-1-[4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl]-, trans-
- Tyk2-IN-8
- PF-06826647
- (1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutanecarbonitrile