N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸
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- CAS号:
- 156719-41-4
- 英文名:
- S-METHYL-L-THIOCITRULLINE
- 英文别名:
- S-MTC;S MTC,SMTC;S-Me-TC, SMTC;L-Thiocitrulline2HCl;s-methylthiocitrulline;H-THIOCIT(S-ME)-OH ACOH;S-METHYL-L-THIOCITRULLINE;S-METHYL-L-THIOCITRULLINE ACETATE;L-Ornithine, N5-[imino(methylthio)methyl]-;(2S)-2-amino-5-[[amino-(methylthio)methylene]amino]valeric acid
- 中文名:
- N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸
- 中文别名:
- 化合物 T16830;N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸
- CBNumber:
- CB0670742
- 分子式:
- C7H15N3O2S
- 分子量:
- 205.28
- MOL File:
- 156719-41-4.mol
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N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸化学性质
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沸点:
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369.4±52.0 °C(Predicted)
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密度:
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1.35±0.1 g/cm3(Predicted)
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储存条件:
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Store at 0°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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2.48±0.24(Predicted)
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N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸性质、用途与生产工艺
S-MTC 是一种选择性的 I 型一氧化氮合酶 (NOS) 抑制剂。
S-MTC (10 or 100 μM) reduces cellular NO release in the absence of Aβ
1-42
. At 100 μM, S-MTC decreases cell viability. S-MTC (100 μM) significantly lowers nitrite production (11.2±1.1 μM) when compared to control (no NOS inhibitor exposure; 19.6±1.2 μM). Nitrite productions after Aβ
1-42
and L-NOARG (100 μM) or Aβ
1-42
and S-MTC (100 μM) treatments are significantly lower than Aβ
1-42
alone (33.5±2.0 and 34.5±1.6 μM, respectively). S-MTC (100 μM) is able to significantly reduce nitrite production (25.2±1.1 μM) as compared to Aβ
1-42
treatment alone (38.3±2.7 μM), when administered after Aβ
1-42
at the 1 h time point. S-MTC (100 μM) concentration decreases both MTT (87±1% of control) and NR (80±1% of control, respectively) levels. The co-administration of S-MTC (100 μM) and Aβ
1-42
significantly reverses the effects of Aβ
1-42
alone (72±2% vs 61±2% of control).
S-MTC (S-methyl-L-thiocitrulline) is a selective neuronal NOS-inhibitor. Following pretreatment with S-MTC (i.c.v.), the HBO
2
-induced antinociception is significantly antagonized. In Experiment #2, different groups of mice are pretreated with naltrexone hydrochloride (NTX) (3.0 mg/kg, i.p.), L-NAME (1.0 μg/mouse, i.c.v.), S-MTC (1.0 μg/mouse, i.c.v.) or N
5
-(1-iminoethyl)-L-ornithine (L-NIO) (3.0 mg/kg, s.c.) 15-30 min prior to HBO
2
treatment. The antinociceptive effect assessed 90 min after HBO
2
treatment is completely abolished by NTX and L-NAME, antagonized by two-thirds by S-MTC and largely unaffected by L-NIO (F=25.57, p<0.0001). At a dose of 0.3 mg/kg, S-MTC (SMTC) causes a rise in mean blood pressure (BP). At doses of 1.0, 3.0 and 10 mg/kg, S-MTC causes falls in heart rate, rises in BP and vasoconstriction in all three vascular beds.
N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸
上下游产品信息
上游原料
下游产品
N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸
生产厂家
156719-41-4, N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸 相关搜索:
- C7H15N3O2SC2H4O2
- C7H15N3O2S
- 化合物 T16830
- N5-[亚氨基(甲硫基)甲基]-L-鸟氨酸
- 156719-41-4
- S MTC,SMTC
- L-Ornithine, N5-[imino(methylthio)methyl]-
- S-MTC
- (S,E)-2-aMino-5-((aMino(Methylthio)Methylene)aMino)pentanoic acid
- S-Me-TC, SMTC
- (2S)-2-azanyl-5-[[azanyl(methylsulfanyl)methylidene]amino]pentanoic acid
- (2S)-2-amino-5-[[amino-(methylthio)methylene]amino]valeric acid
- (2S)-2-amino-5-[[amino(methylsulfanyl)methylidene]amino]pentanoic acid
- L-Thiocitrulline2HCl
- s-methylthiocitrulline
- H-THIOCIT(S-ME)-OH ACOH
- S-METHYL-L-THIOCITRULLINE ACETATE
- S-METHYL-L-THIOCITRULLINE