6-氰基-7-硝基喹喔啉-2,3-二酮
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- CAS号:
- 115066-14-3
- 英文名:
- CNQX
- 英文别名:
- CNQX;CNOX;FG-9065;CNQX 2NA;CNQX DISODIUM;CNQX DISODIUM SALT;CNQX disodium salt hydrate;CNQX DISODIUM KAINATE/AMPA RECEPTOR;CNQX (FG-9065) (6-CYANO-7-NITROQUINO;6-Nitro-7-cyanoquinoxaline-2,3-dione
- 中文名:
- 6-氰基-7-硝基喹喔啉-2,3-二酮
- 中文别名:
- 4-四氢-7-硝基-2;3-二氧代-6-喹喔啉甲腈;CNQX,AMPA /海藻酸盐拮抗剂;6-氰基-7-硝基喹喔啉-2,3-二酮;1,2,3,4-四氢-7-硝基-2,3-二氧代-6-喹喔啉甲腈
- CBNumber:
- CB0728641
- 分子式:
- C9H4N4O4
- 分子量:
- 232.15
- MOL File:
- 115066-14-3.mol
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6-氰基-7-硝基喹喔啉-2,3-二酮化学性质
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熔点:
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300 °C
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沸点:
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374.31°C (rough estimate)
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密度:
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1.5507 (rough estimate)
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折射率:
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1.6590 (estimate)
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RTECS号:
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VD1520000
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储存条件:
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protect from light
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溶解度:
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H2O: 10 mg/mL
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形态:
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solid
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酸度系数(pKa):
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8.16±0.20(Predicted)
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颜色:
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orange to red
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稳定性:
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Store Tightly Sealed at RT
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CAS 数据库:
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115066-14-3(CAS DataBase Reference)
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6-氰基-7-硝基喹喔啉-2,3-二酮性质、用途与生产工艺
CNQX (FG9065) 是一种有效的竞争性 AMPA /海藻酸酯受体 (AMPA/kainate receptor) 拮抗剂,IC50 分别为 0.3 μM 和 1.5 μM。CNQX 是一种竞争性的非 NMDA 受体拮抗剂。CNQX 会阻止大鼠恐惧增强的表达。
IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)
CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
Animal Model:
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Male Wistar rats weighing 180-200 g
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Dosage:
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0.75, 1.5, and 3 mg/kg
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Administration:
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IP; 20 min before testing
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Result:
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Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval
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6-氰基-7-硝基喹喔啉-2,3-二酮
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-15066A | CNQX disodium | | 5 mg | 500元 |
2024/01/25 | HY-15066A | CNQX disodium | | 10 mg | 700元 |
115066-14-3, 6-氰基-7-硝基喹喔啉-2,3-二酮 相关搜索:
6-氰基-7-硝基喹喔啉-2,3-二酮 N-甲基-4-氰基苯胺 1,2,3,4-四氢-6-硝基喹喔啉 2,3-二羟基-6-甲基喹喔啉 1,2,3,4-四氢喹喔啉 2-羟基-6-甲基喹喔啉 3-甲基-4-硝基苯胺 N,N'-二甲基草酰胺 2-硝基苯甲腈 2,5-二氨基苯甲腈 4-乙酰氨苯甲腈 2,3-二羟基喹喔啉 3,4-二氨基苯甲腈 4-ACETAMIDO-2-METHYLNITROBENZENE 6-硝基-2,3-二羟基喹喔啉
- Heterocycles
- Aromatics
- Glutamate
- Glutamate receptor
- Neurochemicals
- Heterocyclic Compounds
- 生化试剂
- 合成
- Ion Channels
- Ionotropic Glutamate Receptor Modulators
- Ligand-Gated Ion Channels
- Cell Biology
- BioChemical
- Cell Signaling and Neuroscience
- C9H4N4O4
- C9H2N4O4Na2
- C9H2N4Na2O4
- 486724-17-2
- CNQX,AMPA /海藻酸盐拮抗剂
- 4-四氢-7-硝基-2
- 3-二氧代-6-喹喔啉甲腈
- 1,2,3,4-四氢-7-硝基-2,3-二氧代-6-喹喔啉甲腈
- 6-氰基-7-硝基喹喔啉-2,3-二酮
- 115066-14-3
- 1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxaline
- CNQX,6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
- 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM SALT
- 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM
- 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 2NA
- 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE
- 6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-
- 7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile
- CNQX disodium salt hydrate
- 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate
- 6-Cyano-2,3-dihydroxy-7-nitroquinoxaline
- 6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
- 7-Nitro-2,3-dihydroxyquinoxaline-6-carbonitrile
- 1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile
- CNOX
- 6-Nitro-7-cyanoquinoxaline-2,3-dione
- 2,3-Dioxo-7-nitroquinoxaline-6-carbonitrile
- CNQX (FG-9065) (6-CYANO-7-NITROQUINO
- CNQX DISODIUM KAINATE/AMPA RECEPTOR
- FG-9065
- CNQX DISODIUM SALT
- CNQX DISODIUM
- CNQX 2NA
- CNQX
- 6-CYANO-7-NITROQUINOXALINE-2,3 (1H,4H)-DIONE
- 7-Nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile