SSM 3 trifluoroacetate
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- CAS号:
- 2320930-10-5
- 英文名:
- SSM 3 trifluoroacetate
- 英文别名:
- SSM3 tetraTFA
- 中文名:
- 中文别名:
- CBNumber:
- CB08202855
- 分子式:
- C24H33F3N12O4
- 分子量:
- 610.6
- MOL File:
- 2320930-10-5.mol
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SSM 3 trifluoroacetate化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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SSM 3 trifluoroacetate性质、用途与生产工艺
SSM3 tetraTFA 是一种有效的合成呋喃啉 (furin) 抑制剂，EC50 和 Ki 分别为 54 nM 和 12 nM。SSM3 tetraTFA 能阻断 furin 依赖的炭疽毒素保护 antigen-83 的细胞表面进程。
EC50: 54 nM (furin)Ki: 12 nM (furin)
SSM3 tetraTFA is against furin cleavage of the Pyr-RTKR-AMC substrate with an EC
50
of 54 nM in vitro cleavage assays and cell-based tests.SSM3 tetraTFA (0.1-25 μM) inhibits the furin-dependent conversion of PA83 into PA63 in a dose dependent manner, it inhibits PA83 processing in the cleavage reactions.SSM3 tetraTFA shows comparable potency against furin (K
i
=0.012 μM) and PC6B (K
i
=0.004 μM), these compounds preferentially inhibited furin over PACE4 (K
i
=0.041 μM) by 2- to 10-fold and over PC7 (K
i
=0.595 μM) by 11- to 76-fold. In addition, it inhibits LF (K
i
=1.241 μM) 25- to 167-fold less effectively than in furin and shows no measurable inhibition against trypsin and MT1-MMP.
SSM 3 trifluoroacetate
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SSM 3 trifluoroacetate
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2320930-10-5, SSM 3 trifluoroacetate 相关搜索:
- 2320930-10-5
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