8-羟基-1,3,6-萘三磺酸
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- CAS号:
- 3316-02-7
- 英文名:
- ζ-Stat
- 英文别名:
- ζ-Stat;NSC37044;ZETA-STAT;ζ-Stat (ZETA-STAT);6-naphthalenetrisulfonicacid,8-hydroxy-3;3,6-Naphthalenetrisulfonicacid,8-hydroxy-1;8-hydroxy-1,3,6-naphthalenetrisulfonic acid;8-hydroxynaphthalene-1,3,6-trisulfonic acid;8-hydroxynaphthalene-1,3,6-trisulphonic acid;1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-
- 中文名:
- 8-羟基-1,3,6-萘三磺酸
- 中文别名:
- 化合物Ζ-STAT;8-羟基-1,3,6-萘三磺酸
- CBNumber:
- CB0860691
- 分子式:
- C10H8O10S3
- 分子量:
- 384.35952
- MOL File:
- 3316-02-7.mol
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8-羟基-1,3,6-萘三磺酸性质、用途与生产工艺
ζ-Stat (NSC37044) 是一种特异且非典型的 PKC-ζ 的抑制剂，IC50 值为 5 μM。ζ-Stat 可以减少黑色素瘤细胞系的增殖并诱导细胞凋亡，在体外具有抗肿瘤活性。
ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level.
ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations.
ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%.
ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells.
ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells.
Cell Proliferation Assay
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Cell Line:
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MEL-F-NEO, SK-MEL-2 and MeWo cells
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Concentration:
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0.1, 0.5, 1, 2.5, 5, 7.5, 10 µM
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Incubation Time:
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3 days
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Result:
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Decreased proliferation by 47.7% for 5 µM in SK-MEL-2 cells and by 50.6% for 5 µM in MeWo cells.
Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM.
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Western Blot Analysis
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Cell Line:
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SK-MEL-2 and MeWo cells
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Concentration:
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5 µM
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Incubation Time:
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3 days
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Result:
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Decreased phosphorylated and total PKC-ζ levels.
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8-羟基-1,3,6-萘三磺酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-123979 | ζ-Stat | | 1 mg | 1200元 |
| 2024/01/25 | HY-123979 | 8-羟基-1,3,6-萘三磺酸
ζ-Stat | 3316-02-7 | 5mg | 3000元 |
3316-02-7, 8-羟基-1,3,6-萘三磺酸 相关搜索:
- 化合物Ζ-STAT
- 8-羟基-1,3,6-萘三磺酸
- 3316-02-7
- antitumor,NSC 37044,melanoma,ζ-Stat,NSC-37044,kinase,NSC37044,Protein kinase C,ΖStat,atypical,Inhibitor,Apoptosis,protein,PKC,Ζ Stat,inhibit,PKC-ζ
- ζ-Stat
- 1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-
- ZETA-STAT
- NSC37044
- ζ-Stat (ZETA-STAT)
- 8-hydroxy-1,3,6-naphthalenetrisulfonic acid
- 8-hydroxynaphthalene-1,3,6-trisulfonic acid
- 8-hydroxynaphthalene-1,3,6-trisulphonic acid
- 6-naphthalenetrisulfonicacid,8-hydroxy-3
- 3,6-Naphthalenetrisulfonicacid,8-hydroxy-1