N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺
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- CAS号:
- 165668-41-7
- 英文名:
- Indisulam
- 英文别名:
- D04522;E-7070;ER-35744;INDISULAM;IndisulaM (E7070);INDISULAM iMpurity;E7070;ER-35744;D04522;Indisulam >=98% (HPLC);IndisulaM (E7070) (ER-35744);N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
- 中文名:
- N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺
- 中文别名:
- 化合物INDISULAM;INDISULAM,分子胶;N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺
- CBNumber:
- CB11011305
- 分子式:
- C14H12ClN3O4S2
- 分子量:
- 385.85
- MOL File:
- 165668-41-7.mol
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N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺化学性质
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熔点:
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242-243 °C (decomp)(Solv: ethanol (64-17-5); water (7732-18-5))
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沸点:
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668.9±65.0 °C(Predicted)
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密度:
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1.663±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO : 100 mg/mL (259.17 mM; Need ultrasonic)
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形态:
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powder
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酸度系数(pKa):
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8.14±0.30(Predicted)
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颜色:
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white to beige
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N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺性质、用途与生产工艺
Indisulam (E7070) 是一种有效的 carbonic anhydrase (CA) 抑制剂,可抑制 cytosolic isozymes I 和 II 以及与肿瘤相关的跨膜 isozyme IX。Indisulam 可抑制 cyclin E 的表达和 CDK2 的磷酸化,这两者对于G1期到S期的转变都是必不可少的。
Target | Value |
CA
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cyclin E
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CDK2
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Indisulam (E7070, 0-50 μg/mL, 12-48 h) causes cell cycle perturbation in the G1 phase in a time- and dose-dependent manner, potentially leading to cell death.
Cell Cycle Analysis
Cell Line:
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P388 murine leukaemia cells.
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Concentration:
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0-50 μg/mL.
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Incubation Time:
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12-48 h.
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Result:
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Accumulated P388 cells in the G1 phase.
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Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models.
Animal Model:
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Female BALB/c nu/nu mice aged 7 weeks (HCT116 colon, LX-1 lung, SW620 colon, HCT115 colon, PC-9 lung, DLD-1 colon and WiDr colon models).
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Dosage:
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12.5, 25, 50 (100) mg/kg.
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Administration:
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IV daily for 4 days.
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Result:
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Exhibited anti-tumor activity.
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N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-13650 | Indisulam | | 1 mg | 293元 |
2024/08/19 | HY-13650 | N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺 Indisulam | 165668-41-7 | 5mg | 700元 |
N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺
生产厂家
165668-41-7, N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺 相关搜索:
- 配体家族
- C14H12ClN3O4S2
- INDISULAM,分子胶
- 化合物INDISULAM
- N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺
- 165668-41-7
- INDISULAM iMpurity
- E-7070,Indisulam,Carbonic Anhydrase,Inhibitor,Carbonate dehydratase,E7070,inhibit
- N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
- Indisulam >=98% (HPLC)
- 1,4-Benzenedisulfonamide, N1-(3-chloro-1H-indol-7-yl)-
- E7070;ER-35744;D04522
- D04522
- N1-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
- IndisulaM (E7070) (ER-35744)
- IndisulaM (E7070)
- ER-35744
- E-7070
- N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
- 1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-
- INDISULAM