Herboxidiene
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- CAS号:
- 142861-00-5
- 英文名:
- Herboxidiene
- 英文别名:
- GEX1A;TAN-1609;Herboxidiene;2-((2R,5S,6S)-6-((S,2E,4E)-7-((2R,3R)-3-((2R,3R,4R)-4-hydroxy-3-methoxypentan-2-yl)-2-methyloxiran-2-yl)-6-methylhepta-2,4-dien-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)acetic acid;L-glycero-L-gluco-Heptitol, 5,6-anhydro-6-C-[(2S,3E,5E)-6-[(2S,3S,6R)-6-(carboxymethyl)tetrahydro-3-methyl-2H-pyran-2-yl]-2-methyl-3,5-heptadien-1-yl]-1,4,7-trideoxy-4-methyl-3-O-methyl-
- 中文名:
- Herboxidiene
- 中文别名:
- 除草二烯
- CBNumber:
- CB11120355
- 分子式:
- C25H42O6
- 分子量:
- 438.6
- MOL File:
- 142861-00-5.mol
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Herboxidiene化学性质
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沸点:
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567.9±35.0 °C(Predicted)
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密度:
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1.056±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO or Ethanol
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酸度系数(pKa):
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4.38±0.10(Predicted)
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形态:
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solid
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颜色:
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White
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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LogP:
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3.459 (est)
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Herboxidiene性质、用途与生产工艺
Herboxidiene (GEX1A) 是一种有效的植物毒性聚酮类化合物,来源于链霉菌 A7847,具有多种活性,包括除草、抗胆固醇、抗肿瘤等。Herboxidiene 通过与剪接体相关蛋白 (SAP) 155 结合抑制前 mRNA 剪接 (pre-mRNA splicing) 过程,SAP 是剪接体中 SF3b 的一个亚单位。
Herboxidiene (24 hours) induces both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38, with an IC
50
of 7.6 nM.
Herboxidiene exhibits cytotoxicity against A431, A549, and DLD-1 cells with IC
50
s of 3.7, 21, 51 nM, respectively.
Herboxidiene (GEX1A) (1 mg/kg; i.p.; once) shows significant antitumor activity.
Animal Model:
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BALB/c mice (bearing SVT2 murine fibrosarcoma)
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Dosage:
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1 mg/kg
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Administration:
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I.p.; once
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Result:
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Showed significant antitumor activity on day 4.
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Herboxidiene
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-19828 | Herboxidiene | | 500 μg | 11700元 |
2024/04/30 | HY-19828 | Herboxidiene Herboxidiene | 142861-00-5 | 1 mg | 18600元 |
142861-00-5, Herboxidiene 相关搜索:
- 除草二烯
- 142861-00-5
- L-glycero-L-gluco-Heptitol, 5,6-anhydro-6-C-[(2S,3E,5E)-6-[(2S,3S,6R)-6-(carboxymethyl)tetrahydro-3-methyl-2H-pyran-2-yl]-2-methyl-3,5-heptadien-1-yl]-1,4,7-trideoxy-4-methyl-3-O-methyl-
- 2-((2R,5S,6S)-6-((S,2E,4E)-7-((2R,3R)-3-((2R,3R,4R)-4-hydroxy-3-methoxypentan-2-yl)-2-methyloxiran-2-yl)-6-methylhepta-2,4-dien-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)acetic acid
- TAN-1609
- GEX1A
- Herboxidiene