GRGDSPK
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- CAS号:
- 111119-28-9
- 英文名:
- GLY-ARG-GLY-ASP-SER-PRO-LYS
- 英文别名:
- GRGDSPK;EMD 56574;GRGDSPK (EMD 56574);GLY-ARG-GLY-ASP-SER-PRO-LYS;H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH;GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE;GRGDSPK, FIBRONECTIN ATTACHMENT PEPTIDE;Gly-Arg-Gly-Asp-Ser-Pro-Lys >=97% (HPLC);glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine;Glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-L-lysine
- 中文名:
- GRGDSPK
- 中文别名:
- 抑制肽EMD 56574;(2S)-6-AMINO-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[(2-AMINOACETYL)AMINO]-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]AMINO]ACETYL]AMINO]-3-CARBOXYPROPANOYL]AMINO]-3-HYDROXYPROPANOYL]PYRROLIDINE-2-CARBONYL]AMINO]HEXANOIC ACID
- CBNumber:
- CB1123649
- 分子式:
- C28H49N11O11
- 分子量:
- 715.76
- MOL File:
- 111119-28-9.mol
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GRGDSPK化学性质
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密度:
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1.59±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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酸度系数(pKa):
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3.60±0.21(Predicted)
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GRGDSPK性质、用途与生产工艺
GRGDSPK (EMD 56574) 是包含精氨酸-甘氨酸-天冬氨酸 (RGD) 的多肽。 GRGDSPK 是一种竞争性且可逆的抑制肽，可抑制整联蛋白-纤连蛋白结合。GRGDSPK 可以用于研究整联蛋白在骨形成和吸收中的作用。
GRGDSPK (EMD 56574; RGD; 0.1-50 μM; for 4 days) inhibits mineralization in a dose-dependent manner as determined by measuring calcium content and 70 bonehnit area of tissue in parietal bones 18 days old isolated from pregnant Sprague-Dawley rats.
GRGDSPK (10, 50 μM; for 4 days) dramatically alteres bone morphology, with a disruption of osteoblast and mineralized matrix organization.
GRGDSPK (RGD; 250 μM), added to the medium, effectively blocks integrin-fibronectin binding and significantly increases the average size of wild-type cell aggregates.
When GRGDSPK (250 μM) is added, wild-type mesendodermal progenitors exhibits strongly reduced adhesion forces and work, indicating that the detachment parameters recorded are specific for fibronectin and that integrins expressed in mesendodermal progenitors are involved.
GRGDSPK (RGD-containing, 1.5 mM, 1.0 mM, and 0.5 mM) and RGD-mod-ified peptides impair the ability of sperm to fertilizebovine oocytes, illustrated by a reduction in cleavage in a dose-dependent manner.
GRGDSPK
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-P0322 | GRGDSPK | | 1 mg | 1737元 |
| 2024/01/25 | HY-P0322 | GRGDSPK
GRGDSPK | 111119-28-9 | 5mg | 3800元 |
111119-28-9, GRGDSPK 相关搜索:
- peptide
- 目录肽
- 标准品
- 对照品
- 多肽
- Cell Biology
- BioChemical
- Cell Signaling and Neuroscience
- Cytoskeleton and Extracellular Matrix
- Extracellular Matrix Peptides and Proteins
- Extracellular Matrix
- C28H49N11O11
- 抑制肽EMD 56574
- (2S)-6-AMINO-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[(2-AMINOACETYL)AMINO]-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]AMINO]ACETYL]AMINO]-3-CARBOXYPROPANOYL]AMINO]-3-HYDROXYPROPANOYL]PYRROLIDINE-2-CARBONYL]AMINO]HEXANOIC ACID
- 111119-28-9
- GRGDSPK (EMD 56574)
- Glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-L-lysine
- Gly-Arg-Gly-Asp-Ser-Pro-Lys >=97% (HPLC)
- L-Lysine, glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-
- EMD 56574
- glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine
- GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE
- GLY-ARG-GLY-ASP-SER-PRO-LYS
- GRGDSPK, FIBRONECTIN ATTACHMENT PEPTIDE
- GRGDSPK
- H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH