盐酸特拉唑嗪
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- CAS号:
- 109351-34-0
- 英文名:
- (R)-Terazosin
- 英文别名:
- (R)-Terazosin;Terazosin-002-R;(R)-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (R)-;Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2R)-tetrahydro-2-furanyl]-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI);(R)-Terazosin,α1-adrenoceptor,affinity,inhibit,subtypes,prove,Adrenergic Receptor,(R)Terazosin,Inhibitor,(R) Terazosin,Low,α2-adrenoceptor,Beta Receptor
- 中文名:
- 盐酸特拉唑嗪
- 中文别名:
- (R)-特拉唑嗪;盐酸特拉唑嗪杂质B;特拉唑嗪标准品2-R
- CBNumber:
- CB11270410
- 分子式:
- C19H25N5O4
- 分子量:
- 387.43
- MOL File:
- 109351-34-0.mol
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盐酸特拉唑嗪化学性质
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沸点:
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664.5±65.0 °C(Predicted)
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密度:
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1.332±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 75 mg/mL (193.58 mM)
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酸度系数(pKa):
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6.52±0.50(Predicted)
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盐酸特拉唑嗪性质、用途与生产工艺
(R)-Terazosin 是 Terazosin 的活性 R 型对应体, 是一种有效的 α1-肾上腺素受体拮抗剂,对 α1a,α1b 和 α1d-肾上腺素受体的 Ki 值分别为 6.51 nM,1.01 nM 和 1.97 nM。
Ki: 6.51 nM (α1a-adrenoceptor), 1.01 nM (α1b-adrenoceptor) and 1.97 nM (α1d-adrenoceptor)
(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with K
i
values of 3.85 μM, 0.33 μM and 0.37 μM, respectively.
(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies.
(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC
30
of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA
2
values of 7.5 and 5.31, respectively.
盐酸特拉唑嗪
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-B0371B | 盐酸特拉唑嗪 (R)-Terazosin | 109351-34-0 | 5mg | 2500元 |
2024/01/25 | HY-B0371B | 盐酸特拉唑嗪 (R)-Terazosin | 109351-34-0 | 10mM * 1mLin DMSO | 2750元 |
109351-34-0, 盐酸特拉唑嗪 相关搜索:
- 杂质对照品
- 对照品-杂质对照品
- (R)-特拉唑嗪
- 盐酸特拉唑嗪杂质B
- 特拉唑嗪标准品2-R
- 109351-34-0
- (R)-Terazosin,α1-adrenoceptor,affinity,inhibit,subtypes,prove,Adrenergic Receptor,(R)Terazosin,Inhibitor,(R) Terazosin,Low,α2-adrenoceptor,Beta Receptor
- Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2R)-tetrahydro-2-furanyl]-
- (R)-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
- Terazosin-002-R
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI)
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (R)-
- (R)-Terazosin