150493-34-8
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- CAS号:
- 150493-34-8
- 英文名:
- 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- 英文别名:
- NS 638;NS638, >98%;NS-638;NS 638;2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine;1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine;1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-;Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
- 中文名:
- 150493-34-8
- 中文别名:
- 化合物NS 638;1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺;1-(4-氯苄基)-5-(三氟甲基)-1H-苯并[D]咪唑-2-胺;1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺, >98%;1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺(NS-638)
- CBNumber:
- CB11344812
- 分子式:
- C15H11ClF3N3
- 分子量:
- 325.72
- MOL File:
- 150493-34-8.mol
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150493-34-8化学性质
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沸点:
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476.3±55.0 °C(Predicted)
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密度:
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1.45±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
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形态:
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A solid
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酸度系数(pKa):
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5.15±0.10(Predicted)
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150493-34-8性质、用途与生产工艺
NS-638是具有阻断Ca2+-离子通道性质的非肽类小分子。细胞内阻断由K+激活的Ca2+浓度升高的IC50值为3.4 μM。
IC50: 3.4 μM (K
+
-stimulated intracellular Ca
2+
-elevation)
NS-638 dose dependently inhibits K
+
-stimulated [45 Ca
2+
]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [
3
H]GABA-release from cultured cortical neurons with IC
50
values of 2.3 and 4.3 μM, respectively. K
+
-stimulated intracellular Ca
2+
-elevation in cultured cerebellar granule cells is equipotently blocked with an IC
50
value of 3.4 μM. At this concentration no effect on Ca
2+
-induced contractions in K
+
-depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca
2+
-channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30 μM.
In the mouse middle cerebral artery occlusion model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.
150493-34-8
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101428 | 150493-34-8
NS-638 | 150493-34-8 | 2mg | 500元 |
| 2024/04/30 | HY-101428 | 150493-34-8
NS-638 | 150493-34-8 | 10mM * 1mLin DMSO | 896元 |
150493-34-8, 150493-34-8 相关搜索:
- 药靶配体
- 1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺(NS-638)
- 1-(4-氯苄基)-5-(三氟甲基)-1H-苯并[D]咪唑-2-胺
- 化合物NS 638
- 1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺, >98%
- 1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺
- 150493-34-8
- Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638
- 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
- 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine
- NS638, >98%
- NS-638;NS 638
- 1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine
- 1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-
- NS 638
- 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole