丁硫氨酸-亚砜亚胺
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- CAS号:
- 83730-53-4
- 英文名:
- L-BUTHIONINE-(S,R)-SULFOXIMINE
- 英文别名:
- L-BSO;nsc326231;L-Butionine sulfoximine;L-BUTHIONINESULPHOXIMINE;L-BUTHIONINE-SULFOXIMINE;D-Buthionine Sulfoximine;L-BUTHIONINE-[S,R]-SULFOXIME;Buthionine - sulfoxide iMine;L-BUTHIONINE-S,R-SULPHOXIMINE;L-BUTHIONINE-(S,R)-SULFOXIMINE
- 中文名:
- 丁硫氨酸-亚砜亚胺
- 中文别名:
- 丁硫氨酸-亚砜亚胺;L-丁硫氨酸亚砜亚胺;L-丁硫氨酸-S,R-磺基;L-丁硫氨酸-(S,R)-亚砜胺;L-蛋氨酸-(S,R)-亚磺酰亚胺;(2S)-2-氨基-4-(丁基磺酰亚胺基)丁酸;(2S)-2-氨基-4-(S-丁基胺基磺酰)丁酸;L-(3-氨基-3-羧丙基)-(S,R)-丁基硫氧亚胺;L-BUTHIONINE-SULFOXIMINE(BSO);丁硫氨酸-亚砜亚胺/(2S)-2-氨基-4-(S-丁基磺酰胺基)丁酸
- CBNumber:
- CB1150667
- 分子式:
- C8H18N2O3S
- 分子量:
- 222.31
- MOL File:
- 83730-53-4.mol
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丁硫氨酸-亚砜亚胺化学性质
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熔点:
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224-228 °C (dec.)
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沸点:
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382.3±52.0 °C(Predicted)
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密度:
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1.29
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折射率:
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1.6300 (estimate)
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储存条件:
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-20°C
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溶解度:
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H2O: 50 mg/mL, clear, colorless to faintly yellow
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形态:
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Fine Powder
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颜色:
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White
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BRN:
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2367136
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
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CAS 数据库:
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83730-53-4
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丁硫氨酸-亚砜亚胺性质、用途与生产工艺
BSO (L-Buthionine-(S,R)-sulfoximine, L-Buthionine sulfoximine) 是一种有效的、可细胞渗透的，作用快的 g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) 的不可逆抑制剂并可耗尽细胞内的谷胱甘肽水平。BSO 在黑色素瘤、乳腺癌和卵巢癌标本上的IC50值分别为1.9 μM、8.6 μM 和 29 μM。
γ-glutamylcysteine synthetase.
L-Buthionine-(S,R)-sulfoximine (BSO: 50 μM) treatment for 48 hr results in a 95% decrease in ZAZ and M14 melanoma cell line GSH levels, and a 60% decrease in GST enzyme activity. GST-π protein and mRNA levels are significantly reduced in both cell lines. L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH).
The average number of eye-spots (mean±SEM) is 5.36±0.29 (n=46), 7.79±0.45 (n=34) and 8.78±0.61 (n=32) in untreated controls, 2 mM L-Buthionine-(S,R)-sulfoximine (BSO) and 20 mM BSO treated mice, respectively. The 2 mM BSO treatment results in ~30% more eye-spots, and the 20 mM treatment results in 40% more eye-spots compared with untreated mice. It is showed that BSO causes an elevated frequency of DNA deletions during mouse development. BSO treatment reduced GSH concentration in mouse fetuses by 55% and 70% at 2 mM and 20 mM BSO doses, respectively, compared to untreated mice. Co-treatment with 2 mM BSO and 20 mM NAC depleted GSH to a similar extent as 2 mM BSO, consistent with the function of BSO to inhibit the g-GCS enzyme indispensable for GSH synthesis. Like GSH, cysteine levels dropped following BSO treatment.
用途
抑制γ谷氨酰半胱氨酸合成酶（在谷胱甘肽合成中的一个关键酶）。
丁硫氨酸-亚砜亚胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-106376A | 丁硫氨酸-亚砜亚胺
L-Buthionine-(S,R)-sulfoximine | 83730-53-4 | 50mg | 600元 |
| 2024/01/25 | HY-106376A | 丁硫氨酸-亚砜亚胺
L-Buthionine-(S,R)-sulfoximine | 83730-53-4 | 10mM * 1mLin Water | 660元 |
丁硫氨酸-亚砜亚胺
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全球有 134家供应商
丁硫氨酸-亚砜亚胺国内生产厂家
83730-53-4, 丁硫氨酸-亚砜亚胺 相关搜索:
- Glutathione S-Transferase Agents
- Chemopreventive Agents
- Cancer Research
- Glutathione biosynthesis and Glu-Cys Ligase
- Enzyme InhibitorsResearch Essentials
- Sulfur & Selenium Compounds
- Enzyme InhibitorsEnzyme Inhibitors by Enzyme
- D to
- Core Bioreagents
- 药靶配体
- 试剂盒-细胞分析试剂盒
- 酶抑制剂
- 细胞生物学
- BioChemical
- Biochemicals and Reagents
- D to K
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
- Enzyme Inhibitors by Type
- Enzymes, Inhibitors, and Substrates
- Glutathione biosynthesis and Glu-Cys Ligase
- Organic Covalent Modifiers
- (2S)-2-氨基-4-(丁基磺酰亚胺基)丁酸
- L-丁硫氨酸-(S,R)-亚砜胺
- (2S)-2-氨基-4-(S-丁基胺基磺酰)丁酸
- L-蛋氨酸-(S,R)-亚磺酰亚胺
- L-(3-氨基-3-羧丙基)-(S,R)-丁基硫氧亚胺
- L-BUTHIONINE-SULFOXIMINE(BSO)
- L-丁硫氨酸-S,R-磺基
- L-丁硫氨酸亚砜亚胺
- 丁硫氨酸-亚砜亚胺/(2S)-2-氨基-4-(S-丁基磺酰胺基)丁酸
- 丁硫氨酸-亚砜亚胺
- 83730-53-4
- L-BSO
- L-Butionine sulfoximine
- Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-, (2S)-
- L-Buthionine-(S,R)-sulfoximine,99%
- (S)-2-Amino-4-(S-butylsulfonimidoyl)butyric acid
- L-Buthionine-(S,R)-sulfoxiMine, 99% 1GR
- -2-Amino-4-(butylsulfonimidoyl)
- Buthionine - sulfoxide iMine
- D-Buthionine Sulfoximine
- (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic Acid
- L-BUTHIONINE-S,R-SULPHOXIMINE
- L-BUTHIONINESULPHOXIMINE
- nsc326231
- L-BUTHIONINE-(S,R)-SULFOXIMINE
- L-BUTHIONINE-[S,R]-SULFOXIME
- L-BUTHIONINE (R,S)-SULFOXIMINE
- L-BUTHIONINE-SULFOXIMINE