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2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
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- CAS号:
- 204205-90-3
- 英文名:
- Indibulin
- 英文别名:
- ZIO 301;Nascapine;Indibulin;lindiblin;2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-;2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide;Indibulin,Apoptosis,ZIO301,D24851,Inhibitor,inhibit,ZIO-301,D-24851,Microtubule/Tubulin;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide ISO 9001：2015 REACH
- 中文名:
- 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
- 中文别名:
- 化合物INDIBULIN;INDIBULIN,微管去稳定剂;2-溴-2-(2-氟苯基)-1-环丙乙酮;2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
- CBNumber:
- CB12128730
- 分子式:
- C22H16ClN3O2
- 分子量:
- 389.83
- MOL File:
- 204205-90-3.mol
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2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺化学性质
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO:33.25(Max Conc. mg/mL);85.29(Max Conc. mM)
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形态:
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A solid
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酸度系数(pKa):
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9.38±0.70(Predicted)
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2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺性质、用途与生产工艺
Indibulin (ZIO 301, D 24851, Zybulin) 是一种口服的 tubulin assembly 抑制剂，并具有有效的抗癌活性。Indibulin 可诱导有丝分裂的停滞和凋亡。
Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM.
Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis.
Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells.
Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells.
Cell Proliferation Assay
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Cell Line:
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MCF-7 cells
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Concentration:
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300, 600, 900, 1200, 1500, 1800, 2100 nM
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Incubation Time:
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48 hours
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Result:
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Inhibited the proliferation of MCF-7 cells with an IC
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of 150 nM.
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Cell Cycle Analysis
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Cell Line:
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MCF-7 cells
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Concentration:
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300, 600 nM
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Incubation Time:
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48 hours
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Result:
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Blocked the cells in the G2/M phase of the cell cycle.
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Apoptosis Analysis
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Cell Line:
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MCF-7 cells
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Concentration:
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150, 300 and 600 nM
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Incubation Time:
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24 hours
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Result:
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Induced apoptosis in MCF-7 cells.
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Western Blot Analysis
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Cell Line:
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MCF-7 cells
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Concentration:
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150, 300 and 600 nM
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Incubation Time:
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48 hours
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Result:
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Generated cleaved fragments of PARP protein in 300 and 600 nM.
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2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-13649 | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
Indibulin | 204205-90-3 | 5mg | 700元 |
| 2024/01/25 | HY-13649 | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
Indibulin | 204205-90-3 | 10mM * 1mLin DMSO | 770元 |
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
生产厂家
204205-90-3, 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 相关搜索:
- Anticancer.
- 药靶配体
- 标准品
- C22H16CIN3O2
- INDIBULIN,微管去稳定剂
- 化合物INDIBULIN
- 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
- 2-溴-2-(2-氟苯基)-1-环丙乙酮
- 204205-90-3
- Indibulin,Apoptosis,ZIO301,D24851,Inhibitor,inhibit,ZIO-301,D-24851,Microtubule/Tubulin
- 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide ISO 9001：2015 REACH
- 1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-
- 2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
- lindiblin
- 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
- Indibulin
- 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
- ZIO 301
- Nascapine