网站主页 >> CAS数据库列表 >> (E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺
(E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺
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- CAS号:
- 168835-82-3
- 英文名:
- (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
- 英文别名:
- CS-1481;CHEMBL261508;SU1498, >98%;Tyrphostin SU 1498, >98%;(E)-2-CYANO-3-(4-HYDROXY-3;AG-1498;TYRPHOSTIN SU 1498;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE;(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy;(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide;2-Propenamide, 2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-, (2E)-
- 中文名:
- (E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺
- 中文别名:
- 化合物SU1498;SU1498,VEGFR2抑制剂;(E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺;(E)-2-氰基-3-(4-羟基-3,5-二异丙基苯基)-N-(3-苯基丙基)丙烯酰胺
- CBNumber:
- CB12514856
- 分子式:
- C25H30N2O2
- 分子量:
- 390.52
- MOL File:
- 168835-82-3.mol
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(E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺化学性质
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熔点:
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126 °C
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沸点:
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590.6±50.0 °C(Predicted)
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密度:
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1.100±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO.
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酸度系数(pKa):
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10.30±0.36(Predicted)
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形态:
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powder
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颜色:
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white to beige
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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CAS 数据库:
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168835-82-3
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(E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺性质、用途与生产工艺
SU1498是KDR抑制剂，IC50为0.7 μM，可在内皮细胞中刺激磷酸化ERK1/2的累积。
SU1498 stimulates accumulation of phosphorylated ERKs in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases. The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective. SU1498 blocks signal transduction from VEGFR2 in MS1 VEGF cells.In the presence of SU1498, levels of Ets-1 are decreased, suggesting that VEGF-VEGFR-2 interactions contributed to baseline levels of Ets-1 expression, and interruption of this autocrine interaction with SU1498 led to decreased expression of Ets-1. SU1498 treatment significantly impacts U87 cell proliferation and apoptosis. SU1498 induces a marked increase in lipids and a decrease in glycerophosphocholine. Accordingly, accumulation of lipid droplets is seen in the cytoplasm of SU1498-treated U87 cells.
(E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | U0103 | SU 1498
SU 1498 | 168835-82-3 | 5mg | 270元 |
| 2024/01/16 | U0103 | SU 1498
SU 1498 | 168835-82-3 | 25mg | 1120元 |
(E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺
生产厂家
168835-82-3, (E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺 相关搜索:
- 生化试剂
- SU1498,VEGFR2抑制剂
- (E)-2-氰基-3-(4-羟基-3,5-二异丙基苯基)-N-(3-苯基丙基)丙烯酰胺
- 化合物SU1498
- (E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺
- 168835-82-3
- Vascular endothelial growth factor receptor,Inhibitor,Su-1498,AG1498,AG-1498,Su1498,Tyrphostin SU1498,inhibit,Tyrphostin SU-1498,VEGFR,SU 1498
- 2-Propenamide, 2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-, (2E)-
- AG-1498;TYRPHOSTIN SU 1498
- SU1498; TYRPHOSTIN SU 1498; CHEMBL261508; (E)-2-CYANO-3-(4-HYDROXY-3;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE
- CHEMBL261508
- 5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE
- (E)-2-CYANO-3-(4-HYDROXY-3
- CS-1481
- Tyrphostin SU 1498, >98%
- SU1498, >98%
- (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy
- (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide