R-雌马酚
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- CAS号:
- 221054-79-1
- 英文名:
- R-Equol
- 英文别名:
- R-Equol;Isoequol;(R)-Equol,99%e.e.;(R)-Equol Exclusive;(3R)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol;2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3R)-;(R)-Equol,(R) Equol,(R)Equol,Inhibitor,Estrogen Receptor/ERR,inhibit
- 中文名:
- R-雌马酚
- 中文别名:
- R-雌马酚;ERΑ和ERΒ激动剂((R)-EQUOL);(R)-3-(4-羟基苯基)四氢苯并吡喃-7-醇
- CBNumber:
- CB12524970
- 分子式:
- C15H14O3
- 分子量:
- 242.27
- MOL File:
- 221054-79-1.mol
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R-雌马酚化学性质
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熔点:
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184-187 °C
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沸点:
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441.7±45.0 °C(Predicted)
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密度:
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1.286±0.06 g/cm3(Predicted)
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溶解度:
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DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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9.94±0.40(Predicted)
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R-雌马酚性质、用途与生产工艺
(R)-Equol 是 ERα 和 ERβ 的激动剂,Ki 值分别为 27.4 和 15.4 nM。
Ki: 27.4 nM (ERα), 15.4 nM (ERβ)
(R)-Equol is an agonist of both ERα and ERβ with K
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s of 27.4 and 15.4 nM, respectively. (R)-Equol induces a dose-dependent inhibitory effect on the invasive capacity of MDA-MB-231 cells that is significant at the highest concentration tested (50 μM). Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035).
Animals fed (R)-Equol have a significantly reduced number of palpable tumors over time when compare with Controls (P=0.002). Furthermore, the number of palpable tumors formed per rat in the (R)-Equol-fed group is significantly lower than that of rats treated with S-(-)equol (P=0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animal is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compare with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003).
R-雌马酚
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-108414 | R-雌马酚 (R)-Equol | 221054-79-1 | 5mg | 770元 |
2024/01/25 | HY-108414 | R-雌马酚 (R)-Equol | 221054-79-1 | 10mM * 1mLin DMSO | 847元 |
221054-79-1, R-雌马酚 相关搜索:
- 细胞生物学试剂
- (R)-3-(4-羟基苯基)四氢苯并吡喃-7-醇
- ERΑ和ERΒ激动剂((R)-EQUOL)
- R-雌马酚
- 221054-79-1
- 2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3R)-
- (R)-Equol,(R) Equol,(R)Equol,Inhibitor,Estrogen Receptor/ERR,inhibit
- Isoequol
- (R)-Equol Exclusive
- (3R)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol
- R-Equol
- (R)-Equol,99%e.e.