7-脱氮-2'-C-乙炔腺苷
|
|
|
- CAS号:
- 1044589-82-3
- 英文名:
- 7-Deaza-2'-C-ethynyladenosine
- 英文别名:
- NITD008;NITD008,NITD-008;2’-b-C-Ethynyltubercidin;2’-b-C-Ethynyl?tubercidin;7-Deaza-2'-C-ethynyladenosine;7-Deaza-2'-C-acetylene-adenosine;7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-ethynyl-β-D-ribofuranosyl)-;(2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- 中文名:
- 7-脱氮-2'-C-乙炔腺苷
- 中文别名:
- 化合物 T16325;2'-C-乙炔基杀结核菌素;2'-C-乙炔基杀结核菌素;7-脱氮-2'-C-乙炔腺苷
- CBNumber:
- CB12562529
- 分子式:
- C13H14N4O4
- 分子量:
- 290.28
- MOL File:
- 1044589-82-3.mol
|
|
|
7-脱氮-2'-C-乙炔腺苷化学性质
-
沸点:
-
631.8±55.0 °C(Predicted)
-
|
-
密度:
-
1?+-.0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
10.48±0.70(Predicted)
-
|
7-脱氮-2'-C-乙炔腺苷性质、用途与生产工艺
NITD008是一种有效的和选择性的黄病毒 (flaviviruses) 抑制剂，抑制登革热病毒2型 (Dengue Virus Type 2 (DENV-2)) 的 EC50 值为0.64 μM。
NITD008 potently inhibits other, including Dengue virus (DENV), West Nile virus, yellow fever virus, and Poissan virus. NITD008 inhibits DENV-2 in a dose-responsive manner, with an EC
50
value of 0.64 μM; treatment with 9 μM compound reduces viral titer by >104-fold. NITD008 also inhibits a luciferase-reporting replicon of hepatitis C virus (HCV, genotype 1b), a member from the genus Hepacivirus, with an EC
50
value of 0.11 μM.
NITD008 is orally bioavailable and has good pharmacokinetic properties. NITD008 exhibits the best pharmacokinetic parameters when formulated using 6 N of HCl (1.5 equimolar amount), 1 N of NaOH (pH adjusted to 3.5), and 100 mM citrate buffer (pH 3.5). Following i.v. injection, NITD008 has a high volume of distribution (3.71 L/kg) and a low systemic clearance (31.11 mL/min per kg), resulting in a long elimination half-life (t
1/2
=4.99 h). After p.o. dosing, NITD008 is rapidly absorbed (time of peak plasma concentration=0.5 h), with a maximal plasma concentration of 3 μM and bioavailability of 48%. Treatment of the mice immediately after viral infection with 1 mg/kg of NITD008 does not reduce mortality, but treatment with 3 mg/kg partially protects and treatment with ≥10 mg/kg completely protects the infected mice from death. NITD008 can suppress peak viremia, decrease cytokine elevation, and prevent death.
7-脱氮-2'-C-乙炔腺苷
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-12957 | 7-脱氮-2'-C-乙炔腺苷
NITD008 | 1044589-82-3 | 5mg | 3500元 |
| 2024/01/25 | HY-12957 | 7-脱氮-2'-C-乙炔腺苷
NITD008 | | 10 mM * 1 mLin DMSO | 3850元 |
1044589-82-3, 7-脱氮-2'-C-乙炔腺苷 相关搜索:
- 2'-C-乙炔基杀结核菌素
- 2'-C-乙炔基杀结核菌素
- 化合物 T16325
- 7-脱氮-2'-C-乙炔腺苷
- 1044589-82-3
- 2’-b-C-Ethynyltubercidin
- 7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 2’-b-C-Ethynyl?tubercidin
- NITD008,NITD-008
- NITD008
- 7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-ethynyl-β-D-ribofuranosyl)-
- 7-Deaza-2'-C-acetylene-adenosine
- (2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- 7-Deaza-2'-C-ethynyladenosine