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网站主页 >> CAS数据库列表 >> (3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇

(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇

生物活性 靶点 体外研究

(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇, 1262849-73-9, 结构式
(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇
CAS号:
1262849-73-9
英文名:
CCT241533
英文别名:
CS-198;CCT241533;CCT241533 (CCT 241533;4-Fluoro-2-(4-(((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol;3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, (3R,4S)-;(3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol
中文名:
(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇
中文别名:
化合物 T10718;(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇
CBNumber:
CB12570371
分子式:
C23H27FN4O4
分子量:
442.4832832
MOL File:
1262849-73-9.mol

(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇化学性质

沸点:
569.4±50.0 °C(Predicted)
密度:
1.327
储存条件:
Store at -20°C
溶解度:
Soluble in DMSO
形态:
crystalline solid
酸度系数(pKa):
8.18±0.48(Predicted)
安全信息

(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇性质、用途与生产工艺

生物活性

CCT241533 是有效，选择性的 CHK2 抑制剂，IC50 和 Ki 分别为 3 nM 和 1.16 nM。

靶点

Chk2

3 nM (IC 50 )

Chk1

245 nM (IC 50 )

Chk2

1.16 nM (Ki)

体外研究

CCT241533 hydrochloride inhibits CHK2 with an IC 50 of 3 nM and shows minimal cross reactivity against a panel of kinases at 1 μM. X-ray crystallography confirms that CCT241533 binds to CHK2 in the ATP pocket. CCT241533 blocks CHK2 activity in human tumor cell lines in response to DNA damage, as demonstrated by inhibition of CHK2 autophosphorylation at S516, band-shift mobility changes and HDMX degradation. CCT241533 does not potentiate the cytotoxicity of a selection of genotoxic agents in several cell lines. However, CCT241533 significantly potentiates the cytotoxicity of two structurally distinct PARP inhibitors. Clear induction of the pS516 CHK2 signal is seen with a PARP inhibitor alone and this activation is abolished by CCT241533. The cytotoxicity of CCT241533 in HT-29, HeLa and MCF-7, measured as the growth inhibitory IC 50 (GI 50 ) by SRB assay, is 1.7, 2.2 and 5.1 μM, respectively. CCT241533 hydrochloride is a potent CHK2 inhibitor (IC 50 =3 nM), with selectivity (63-fold) over CHK1(IC 50 =190 nM) and low hERG inhibition (IC 50 =22 μM).

(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇 上下游产品信息

上游原料

下游产品

(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇 生产厂家

全球有 44家供应商   (3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇国内生产厂家
供应商联系电话电子邮件国家产品数优势度
上海佰世凯化学科技有限公司 021-20908456 sales@BioChemBest.com 中国 6011 61
Wuhan NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 中国 1494 55
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四川省维克奇生物科技有限公司 028-81700200 18116577057 3003855609@qq.com 中国 7892 56
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Musechem +1-800-259-7612 info@musechem.com 美国 4662 60
范德(北京)生物科技有限责任公司 15911056312 liming@bio-fount.com 中国 9730 58
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上海源溪生物科技有限公司 021-58447131 13564518121 sales@dcchemicals.com 中国 9414 58
Cckinase, Inc. +1 (732)236-3202 sales@cckinase.com 美国 2738 58
河南科锐化工有限公司 +86-0371-86658258 15093356674 factory@coreychem.com 中国 29826 58
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MedBio脉铂医药 021-69568360 18916172912 order@med-bio.cn 中国 8141 58
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Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 info@chemextension.com 中国 42057 58
ApexBio技术 sales@apexbt.com 美国 6254 58
 

1262849-73-9, (3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇 相关搜索:

  • 对照品
  • 细胞周期
  • 化合物 T10718
  • (3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇
  • 1262849-73-9
  • 4-Fluoro-2-(4-(((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol
  • 3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, (3R,4S)-
  • CS-198
  • CCT241533 (CCT 241533
  • CCT241533
  • (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol
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