远志皂苷D
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- CAS号:
- 66663-91-0
- 英文名:
- Polygalacin D
- 英文别名:
- Onjisaponin D;Polygalacin D;Polygalacin D2;Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23-trihydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,4β,16α)-
- 中文名:
- 远志皂苷D
- 中文别名:
- 远志皂苷D;远志皂苷D2
- CBNumber:
- CB12614224
- 分子式:
- C57H92O27
- 分子量:
- 1209.34
- MOL File:
- 66663-91-0.mol
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远志皂苷D化学性质
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密度:
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1.54±0.1 g/cm3 (20 ºC 760 Torr)
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储存条件:
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4°C, protect from light
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溶解度:
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Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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形态:
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Powder
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酸度系数(pKa):
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12.76±0.70(Predicted)
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远志皂苷D性质、用途与生产工艺
化学式：C57H92O27
CAS号：66663-91-0
熔点： 221-226
比旋光度： -41.5 (c, 1 in MeOH)
分子量：1209.32000
外观： 白色针状晶体
纯度： ≥ 98%
溶解性： 可溶于水、乙醇、甲醇等溶剂，不溶于石油醚、氯仿、乙酸乙酯。
分子结构式：
远志科植物
促进智力、减少心肌损伤、镇咳和祛痰作用。用于含量测定/鉴定/药理实验等。
4℃冷藏、密封、避光
http://www.chemsrc.com/cas/66663-91-0_69204.html
http://www.shyuanye.com/goods-B21629.html
Polygalacin D (PGD) 是从桔梗 Platycodon grandiflorum 中分离的具有抗癌和抗增殖特性的生物活性化合物。
Polygalacin D 抑制 IAP 蛋白家族的表达，包括存活蛋白，cIAP-1 和 cIAP-2 蛋白，并通过抑制 GSK3β，Akt 的磷酸化和PI3K 的表达来阻断 PI3K/Akt 途径。Polygalacin D 通过 PI3K/Akt 途径诱导凋亡 (apoptosis)。
Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC
50
s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells.
Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells.
Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells.
Cell Proliferation Assay
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Cell Line:
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A549 and H460 cancer cell lines
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Concentration:
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10 µM, 20 µM, 40µM
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Incubation Time:
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48 hours
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Result:
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Inhibited the proliferation of NSCLC cell lines.
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Apoptosis Analysis
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Cell Line:
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A549 and H460 cancer cell lines
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Concentration:
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10 µM, 20 µM
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Incubation Time:
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48 hours
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Result:
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Induced apoptosis of NSCLC cell lines.
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Western Blot Analysis
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Cell Line:
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A549 and H460 cancer cell lines
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Concentration:
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10 µM, 20 µM
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Incubation Time:
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48 hours
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Result:
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Decreased survivin, c-IAP-1 and c-IAP-2 expression.
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远志皂苷D
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-N6064 | 远志皂苷D
Polygalacin D | 66663-91-0 | 1mg | 1520元 |
| 2024/01/25 | HY-N6064 | 远志皂苷D
Polygalacin D | 66663-91-0 | 5mg | 4570元 |
66663-91-0, 远志皂苷D 相关搜索:
- 标准品-对照品
- 标准品，对照品
- 植物提取物
- 中药对照品
- 对照品
- 标准品
- C57H92O27
- 远志皂苷D2
- 远志皂苷D
- 66663-91-0
- Polygalacin D2
- Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23-trihydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,4β,16α)-
- Onjisaponin D
- Polygalacin D