新霉胺
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- CAS号:
- 3947-65-7
- 英文名:
- (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
- 英文别名:
- NEAMINE;Neamine CRS;U-5214;neamin;C01441;Negamicin;neomycina;dekamycinv;nebramycinx;Framycetin EP Impurity A
- 中文名:
- 新霉胺
- 中文别名:
- 新霉胺;新黴素A;新霉素杂质A;工厂已不再生产;新霉素 EP标准品;硫酸新霉素杂质 A;新霉素杂质A(EP);硫酸新霉素EP杂质A;硫酸弗雷米锡EP杂质A;硫酸新霉素EP杂质A(NEAMINE)
- CBNumber:
- CB1262623
- 分子式:
- C12H26N4O6
- 分子量:
- 322.36
- MOL File:
- 3947-65-7.mol
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新霉胺化学性质
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熔点:
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225.5°C (rough estimate)
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沸点:
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460.98°C (rough estimate)
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比旋光度:
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D25+112.8° (c = 1)
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密度:
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1.1885 (rough estimate)
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折射率:
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1.6120 (estimate)
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储存条件:
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Hygroscopic, Refrigerator, Under inert atmosphere
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溶解度:
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Aqueous Acid (Slightly), Methanol (Slightly, Heated), Water (Slightly)
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酸度系数(pKa):
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13.24±0.70(Predicted)
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颜色:
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White to Pale Yellow
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稳定性:
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Hygroscopic
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新霉胺性质、用途与生产工艺
Neamine 是一种 Neomycin 的无毒衍生物，也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌，抗肿瘤和神经保护活性。
Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM.
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively.
Cell Proliferation Assay
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Cell Line:
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AsPC-1 cells
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Concentration:
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0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM
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Incubation Time:
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48 hours
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Result:
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Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.
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Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.
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Animal Model:
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Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells
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Dosage:
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30 mg/kg, 60 mg/kg
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Administration:
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Subcutaneous injection; daily; for 14 days
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Result:
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Had anti-tumor effects on AsPC-1 xenograft models.
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新霉胺
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3947-65-7, 新霉胺 相关搜索:
- Intermediates
- 杂质对照品
- 对照品-杂质对照品
- C12H26N4O6
- 妥布霉素杂质3 (妥布霉素杂质 C )(新霉胺)
- 硫酸新霉素杂质1(硫酸新霉素EP杂质A)
- 硫酸新霉素EP杂质A(妥布霉素EP杂质C)(新霉胺对照品)
- 硫酸新霉素杂质 A
- 硫酸新霉素EP杂质A(NEAMINE)
- 硫酸弗雷米锡EP杂质A
- 新霉素 EP标准品
- 新霉素杂质A
- 新霉素杂质A(EP)
- 硫酸新霉素EP杂质A
- 工厂已不再生产
- 新黴素A
- 新霉胺
- 3947-65-7
- Neomycin A Sulfate (Neamine), EvoPure
- Neomycin Sulfate EP Impurity A（Tobramycin EP Impurity C）
- 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine (neamine)
- 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine (neamine or neomycin A-LP)
- Neamine (synonym: Neomycin Sulfate EP Impurity A)
- Neamine CRS
- NEAMINE
- Neomycin Sulfate EP Impurity A (Neamine)Q: What is
Neomycin Sulfate EP Impurity A (Neamine) Q: What is the CAS Number of
Neomycin Sulfate EP Impurity A (Neamine) Q: What is the storage condition of
Neomycin Sulfate EP Impurity A (Neamine) Q: What are the applications of
Neomycin Sulfate EP Impurity A (Neamine)
- Neamine (N0300000)Q: What is
Neamine (N0300000) Q: What is the CAS Number of
Neamine (N0300000) Q: What are the applications of
Neamine (N0300000)
- Framycetin sulfate EP Impurity A
- Framycetin Impurity 1 (Framycetin EP Impurity A)
- (1R,3S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
- (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4-diol
- Tobramycin Impurity 3 (Tobramycin EP Impurity C) (Neamine)
- Framycetin EP Impurity A
- D-Streptamine, 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-
- Neomycin Sulfate EP Impurity A
- Neomycin Sulfate EP Impurity A (Neamine)
- Neomycin Sulfate Impurity 1（Neomycin Sulfate EP Impurity A）
- Neomycin sulfate impurity A
- 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine (neamine or neomycin A-LP)
- 5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol
- Neomycin A sulfate (Neamine)
- C01441
- Negamicin
- 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine
- neomycina
- nebramycinx
- neamin
- dekamycinv
- (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
- 2-deoxy-4-o-(2,6-diamino-2,6-dideoxy-alpha-d-glucopyranosyl)-d-streptamin
- U-5214
- 5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL