AL 082D06游离态
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- CAS号:
- 256925-03-8
- 英文名:
- D 06
- 英文别名:
- D 06;AL082D06;AL-082D06;AL 082D06;AL 082D06(D-06);AL-082D06; D06; D-06;AL082D06;4,4'-((2-Chloro-5-nitrophenyl)methylene)bis(N,N-dimethylaniline);4,4'-((2-Chloro-5-nitrophenyl)methylene)bis(N,N-dimethylaniline);4,4'-[(2-Chloro-5-nitrophenyl)methylene]bis[N,N-dimethylbenzenamine];Benzenamine, 4,4'-[(2-chloro-5-nitrophenyl)methylene]bis[N,N-dimethyl-
- 中文名:
- AL 082D06游离态
- 中文别名:
- 化合物AL082D06;AL 082D06游离态;4,4'-((2-氯-5-硝基苯基)亚甲基)双(N,N-二甲基苯胺);4,4'-((2-氯-5-硝基苯基)亚甲基)双(N,N-二甲基苯胺)
- CBNumber:
- CB12667194
- 分子式:
- C23H24ClN3O2
- 分子量:
- 409.91
- MOL File:
- 256925-03-8.mol
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AL 082D06游离态化学性质
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沸点:
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543.7±50.0 °C(Predicted)
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密度:
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1.232±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO:6.25(Max Conc. mg/mL);15.25(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);24.4(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.81(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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5.36±0.24(Predicted)
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AL 082D06游离态性质、用途与生产工艺
AL082D06是非类固醇的糖皮质激素受体拮抗剂，而对与其高度相关受体如盐皮质激素、雄激素、雌激素和孕酮等无显著结合亲和力。
| Target | Value |
Glucocorticoid receptor
()
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210 nM(Ki)
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AL 082D06 (D06) binds specifically to GR with nanomolar affinity. Addition of AL 082D06 causes a dose-dependent decrease in transcriptional activation from the MMTV:Luc reporter stimulated with half-maximal DEX concentrations. AL 082D06 acts to antagonize reporter activity using several glucocorticoid-responsive promoter- reporter systems including the 3-kb tyrosine amino transferase (TAT) promoter and less complex promoters comprised of isolated glucocorticoid response element (GRE) sequences. AL 082D06 competes with
3
H-Dex for baculovirus-expressed GR with nanomolar affinity. Other intracellular receptors (AR, ER, PR, and MR) have no affinity for AL 082D06 in a similarly structured binding assay with the appropriate receptor and tritiated ligand (>2500 nM). AL 082D06 has no activation efficacy on the progesterone, androgen, mineralocorticoid, retinoid, glucocorticoid, or estrogen receptors. AL 082D06 is very efficacious at antagonizing GR activity but exhibits much weaker efficacy when tested against the other steroid receptors in contrast to the reference antagonists used as controls.
AL 082D06游离态
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15709 | AL 082D06游离态
AL 082D06 | 256925-03-8 | 2mg | 2000元 |
| 2024/01/25 | HY-15709 | AL 082D06游离态
AL 082D06 | 256925-03-8 | 10mM * 1mLin DMSO | 2705元 |
256925-03-8, AL 082D06游离态 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂，天然产物
- 小分子抑制剂
- 4,4'-((2-氯-5-硝基苯基)亚甲基)双(N,N-二甲基苯胺)
- 4,4'-((2-氯-5-硝基苯基)亚甲基)双(N,N-二甲基苯胺)
- 化合物AL082D06
- AL 082D06游离态
- 256925-03-8
- 4,4'-((2-Chloro-5-nitrophenyl)methylene)bis(N,N-dimethylaniline)
- inhibit,Glucocorticoid Receptor,Inhibitor,D 06,AL 082D-06,D06,AL 082D06
- 4,4'-((2-Chloro-5-nitrophenyl)methylene)bis(N,N-dimethylaniline)
- Benzenamine, 4,4'-[(2-chloro-5-nitrophenyl)methylene]bis[N,N-dimethyl-
- 4-[(2-Chloro-5-nitrophenyl)-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline
- AL-082D06; D06; D-06;AL082D06
- 4,4'-[(2-Chloro-5-nitrophenyl)methylene]bis[N,N-dimethylbenzenamine]
- AL 082D06(D-06)
- D 06
- AL-082D06
- AL082D06
- AL 082D06