GKA-50; GKA 50
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- CAS号:
- 851884-87-2
- 英文名:
- GKA-50
- 英文别名:
- GKA50;GKA-50;GKA 50;GKA-50; GKA 50;OCBMECSFDVUYQN-ROUUACIJSA-N;6-[[3-[(1S)-2-Methoxy-1-Methylethoxy]-5-[(1S)-1-Methyl-2-phenylethoxy]benzoyl]aMino]-3-pyridinecarboxylic Acid;3-Pyridinecarboxylic acid, 6-[[3-[(1S)-2-methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-
- 中文名:
- GKA-50; GKA 50
- 中文别名:
- 化合物 T11401
- CBNumber:
- CB12667462
- 分子式:
- C26H28N2O6
- 分子量:
- 464.51
- MOL File:
- 851884-87-2.mol
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GKA-50; GKA 50化学性质
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沸点:
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607.0±55.0 °C(Predicted)
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密度:
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1.247±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble15mg/mL, clear
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形态:
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powder
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酸度系数(pKa):
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3.49±0.10(Predicted)
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颜色:
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white to beige
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GKA-50; GKA 50性质、用途与生产工艺
GKA50 是一种有效的葡萄糖激酶 (glucokinase) 激活剂 (EC50=33 nM)。GKA50 刺激小鼠胰岛和 MIN6 细胞分泌胰岛素。GKA50 对高脂高脂脂肪雌性大鼠有显著的降糖作用。
GKA50 (0.01-100 μM; 24 hours) enhances INS-1 cell proliferation with EC
50
values ranging from 1 to 2 μM.
GKA50 (1.2 μM+40 μM glucose; 2-4 days) treatment reduces apoptosis induced by chronic high glucose in INS-1 cells.
GKA50 activates human glucokinase enzymatic activity with an EC
50
of 0.022 μM. GKA50 stimulates insulin secretion in the pancreatic insulinoma cell line, INS-1, with an EC
50
of 0.065 μM. GKA50 reduces chronic-high-glucose-induced apoptosis via modulation of glucokinase and apoptotic protein BAD.
Cell Proliferation Assay
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Cell Line:
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INS-1 cells (starved overnight with 3 μM glucose)
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Concentration:
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0.01-100 μM
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Incubation Time:
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24 hours
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Result:
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Stimulated cell proliferation in a dose-dependent manner, with EC
50
values ranging from 1 to 2 μM.
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GKA50 (1-30 mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test.
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Animal Model:
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High-fat-fed obese female Zucker (fa/fa) rats
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Dosage:
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1, 3, 10, 30 mg/kg
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Administration:
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Oral administration
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Result:
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Significant percentage glucose lowering.
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GKA-50; GKA 50
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15671 | GKA-50; GKA 50
GKA50 | 851884-87-2 | 1mg | 650元 |
| 2024/04/30 | HY-15671 | GKA-50; GKA 50
GKA50 | 851884-87-2 | 5mg | 1600元 |
851884-87-2, GKA-50; GKA 50 相关搜索:
- 化合物 T11401
- 851884-87-2
- 3-Pyridinecarboxylic acid, 6-[[3-[(1S)-2-methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-
- GKA-50; GKA 50
- OCBMECSFDVUYQN-ROUUACIJSA-N
- 6-[[3-[(1S)-2-Methoxy-1-Methylethoxy]-5-[(1S)-1-Methyl-2-phenylethoxy]benzoyl]aMino]-3-pyridinecarboxylic Acid
- GKA-50
- GKA50
- GKA 50