4(二(1H-吲哚-3-基)甲基)苯酚
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- CAS号:
- 151358-47-3
- 英文名:
- 4-(di(1H-indol-3-yl)Methyl)phenol
- 英文别名:
- C-DIM8;DIM-C-pPhOH;DIM-C-pPhOH(CDIM8);4-(di(1H-indol-3-yl)Methyl)phenol;4-[bis(1H-indol-3-yl)methyl]phenol;Phenol, 4-(di-1H-indol-3-ylmethyl)-;1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane;1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane;inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress
- 中文名:
- 4(二(1H-吲哚-3-基)甲基)苯酚
- 中文别名:
- 化合物DIM-C-PPHOH;4(二(1H-吲哚-3-基)甲基)苯酚;DIM-C-PPHOH,NUR77拮抗剂
- CBNumber:
- CB12682261
- 分子式:
- C23H18N2O
- 分子量:
- 338.4
- MOL File:
- 151358-47-3.mol
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4(二(1H-吲哚-3-基)甲基)苯酚化学性质
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熔点:
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122-124 °C
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沸点:
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610.2±50.0 °C(Predicted)
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密度:
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1.321±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
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形态:
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solid
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酸度系数(pKa):
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9.98±0.26(Predicted)
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颜色:
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Pink
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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4(二(1H-吲哚-3-基)甲基)苯酚性质、用途与生产工艺
DIM-C-pPhOH (C-DIM8, CDIM8)是一种 nuclear receptor 4A1 (NR4A1)(Nur77) 拮抗剂。DIM-C-pPhOH 可抑制肿瘤生长和mTOR信号传导，并诱导细胞凋亡和细胞应激。DIM-C-pPhOH 可降低细胞增殖，其对 ACHN细胞 和 786-O细胞 的IC50值分别为13.6 μM 和 13.0 μM。
| Target | Value |
Nur77
(786-O cells based assay)
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13.0 μM
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Nur77
(ACHN cells based assay)
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13.6 μM
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DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.
DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.
DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.
DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines.
Cell Proliferation Assay
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Cell Line:
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ACHN and 786-O cells
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Concentration:
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7.5 μM, 15 μM, 20 μM
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Incubation Time:
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24 hours
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Result:
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Significantly decreased cell proliferation.
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Apoptosis Analysis
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Cell Line:
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ACHN and 786-O cells
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Concentration:
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20 μM
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Incubation Time:
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24 hours
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Result:
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Induced apoptosis in ACHN and 786-O cells.
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Western Blot Analysis
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Cell Line:
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ACHN and 786-O cells
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Concentration:
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15 μM, 20 μM
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Incubation Time:
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24 hours
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Result:
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Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases.
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DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.
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Animal Model:
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Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells
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Dosage:
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30 mg/kg/day
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Administration:
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Oral gavage; daily; for 50 days
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Result:
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Resulted in a significant inhibition of tumor growth.
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4(二(1H-吲哚-3-基)甲基)苯酚
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚
DIM-C-pPhOH | 151358-47-3 | 1mg | 500元 |
| 2024/04/30 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚
DIM-C-pPhOH | 151358-47-3 | 5mg | 750元 |
151358-47-3, 4(二(1H-吲哚-3-基)甲基)苯酚 相关搜索:
- 药靶配体
- 化工试剂
- 抑制剂
- 吲哚类
- DIM-C-PPHOH,NUR77拮抗剂
- 化合物DIM-C-PPHOH
- 4(二(1H-吲哚-3-基)甲基)苯酚
- 151358-47-3
- 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
- inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress
- Phenol, 4-(di-1H-indol-3-ylmethyl)-
- DIM-C-pPhOH(CDIM8)
- 1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
- C-DIM8
- 4-[bis(1H-indol-3-yl)methyl]phenol
- DIM-C-pPhOH
- 4-(di(1H-indol-3-yl)Methyl)phenol